Dimethyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

Base Information

Chemical Name:Dimethyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate
CAS No.:99446-50-1
Molecular Formula:C₁₁H₁₀N₂O₄
Molecular Weight:234.211
Hs Code.:

Synonyms:Dimethyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate;Pyrazolo[1,5-a]pyridine-3,5-dicarboxylic acid, 3,5-dimethyl ester

Suppliers and Price of Dimethyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 7 raw suppliers

Chemical Property of Dimethyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of Dimethyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

There total 2 articles about Dimethyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 59247-63-1
1-amino-4-(methoxycarbonyl)pyridin-1-ium 2,4,6-trimethylbenzene-1-sulfonate

: 922-67-8
propynoic acid methyl ester

: 99446-50-1
dimethyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

Guidance literature:: With triethylamine; at 20 ℃; for 0.25h;
DOI:10.1055/s-0036-1588799

Reference yield:

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 922-67-8
propynoic acid methyl ester

: 99446-50-1
dimethyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

Guidance literature:: 4-pyridinecarboxylic acid, methyl ester; With O-(2,4-dinitrophenyl)hydroxylamine; In acetonitrile; at 40 ℃; for 18h;

propynoic acid methyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 4h;

Reference yield:

: 99446-50-1
dimethyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate

: 3-(cyclopenten-1-yl)-N-(3,4,5-trifluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; water / 4 h / 100 °C

2: hydrogen; palladium on activated charcoal / methanol / 12 h / 60 °C / 2585.81 Torr

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 25 °C

4: N-iodo-succinimide / dichloromethane / 12 h / 25 °C

5: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 12 h / 90 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; sulfuric acid; palladium on activated charcoal; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;