Methyl 5-broMo-6-cyanopicolinate

Base Information

• Chemical Name: Methyl 5-broMo-6-cyanopicolinate
• CAS No.: 959741-33-4
• Molecular Formula: C₈H₅BrN₂O₂
• Molecular Weight: 241.044
• Hs Code.: 2933399090
• Mol file: 959741-33-4.mol

Synonyms:Methyl 5-broMo-6-cyanopicolinate

Chemical Property of Methyl 5-broMo-6-cyanopicolinate

Chemical Property:

• PSA: 62.98000
• LogP: 1.50238
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-bromo-6-cyanopicolinate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-broMo-6-cyanopicolinate

There total 2 articles about Methyl 5-broMo-6-cyanopicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-bromo-2-(methoxycarbonyl)-1A[5]-pyridin-1-olate (959741-32-3) + trimethylsilyl cyanide (7677-24-9) → methyl 5-bromo-6-cyanopyridine-2-carboxylate (959741-33-4)

Guidance literature:

With N,N-Dimethylcarbamoyl chloride; at 50 ℃; for 16h;

Reference yield:

methyl 5-bromopicolinate (29682-15-3) → methyl 5-bromo-6-cyanopyridine-2-carboxylate (959741-33-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 45 °C

2: N,N-Dimethylcarbamoyl chloride / 16 h / 50 °C

With 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In dichloromethane;

Reference yield: 100.0%

methyl 5-bromo-6-cyanopyridine-2-carboxylate (959741-33-4) → 5-bromo-6-cyano-pyridine-2-carboxylic acid (959741-34-5)

Guidance literature:

methyl 5-bromo-6-cyanopyridine-2-carboxylate; With (trimethylsilyl)potassium; In tetrahydrofuran; at 50 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 0.5h;

upstream raw materials:

5-bromo-2-(methoxycarbonyl)-1^A[5]-pyridin-1-olate

trimethylsilyl cyanide

methyl 5-bromopicolinate

Downstream raw materials:

5-bromo-6-cyano-pyridine-2-carboxylic acid