(2-Chloro-4-methoxyphenyl)methanol

Base Information

• Chemical Name: (2-Chloro-4-methoxyphenyl)methanol
• CAS No.: 334018-24-5
• Molecular Formula: C8H9ClO2
• Molecular Weight: 172.611
• Hs Code.: 2909499000
• European Community (EC) Number: 878-153-5
• Mol file: 334018-24-5.mol

Synonyms:334018-24-5;(2-Chloro-4-methoxyphenyl)methanol;2-chloro-4-methoxybenzyl alcohol;(2-Chloro-4-methoxy-phenyl)-methanol;SCHEMBL5753110;2-Chloro-4-methoxybenzenemethanol;IORXRKZALSZEPL-UHFFFAOYSA-N;MFCD16037274;AKOS013400750;SB36657;BS-28302;CS-0194396;W19191;EN300-1983846;J-508754

Chemical Property of (2-Chloro-4-methoxyphenyl)methanol

Chemical Property:

• PSA: 29.46000
• LogP: 1.84090
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 172.0291072
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-4-methoxybenzylalcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)CO)Cl

Technology Process of (2-Chloro-4-methoxyphenyl)methanol

There total 6 articles about (2-Chloro-4-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-chloro-4-methoxybenzaldehyde (54439-75-7) → (2-chloro-4-methoxyphenyl)methanol (334018-24-5)

Guidance literature:

With sodium borohydrid; In methanol; ethyl acetate;

Reference yield: 96.0%

2-chloro-4-methoxybenzoic acid (21971-21-1) → (2-chloro-4-methoxyphenyl)methanol (334018-24-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1h; Heating;

DOI:10.1021/jm00171a031

Reference yield:

2-chloro-4-methoxyacetophenone (41068-36-4) → (2-chloro-4-methoxyphenyl)methanol (334018-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Br₂, aq. NaOH / 1.) 10 deg C, 2.) dioxane, RT, 1 h

2: 96 percent / LiAlH₄ / diethyl ether / 1 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; bromine; In diethyl ether;

DOI:10.1021/jm00171a031

upstream raw materials:

2-chloro-4-methoxybenzoic acid

2-chloro-4-methoxyacetophenone

1-chloro-3-methoxy-benzene

2-chloro-4-methoxybenzaldehyde

Downstream raw materials:

2-chloro-4-methoxybenzyl chloride

2-chloro-4-methoxybenzyl bromide

2-[(E)-2-(2-chloro-4-methoxyphenyl)ethenyl]-5-methoxy-1H-indole

4-(2-chloro-4-methoxyphenyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione