2-Chloro-1-(chloromethyl)-4-methoxybenzene

Base Information

• Chemical Name: 2-Chloro-1-(chloromethyl)-4-methoxybenzene
• CAS No.: 101080-63-1
• Molecular Formula: C₈H₈Cl₂O
• Molecular Weight: 191.057
• European Community (EC) Number: 969-460-6
• Mol file: 101080-63-1.mol

Synonyms:2-Chloro-1-(chloromethyl)-4-methoxybenzene;101080-63-1;Benzene, 2-chloro-1-(chloromethyl)-4-methoxy-;2-chloro-4-methoxybenzyl chloride;SCHEMBL4510419;VCCMJKRDVTXQQC-UHFFFAOYSA-N;BEA08063;EN300-93856;G28693;A907348

Chemical Property of 2-Chloro-1-(chloromethyl)-4-methoxybenzene

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 189.9952203
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)CCl)Cl

Technology Process of 2-Chloro-1-(chloromethyl)-4-methoxybenzene

There total 5 articles about 2-Chloro-1-(chloromethyl)-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2-chloro-4-methoxyphenyl)methanol (334018-24-5) → 2-chloro-4-methoxybenzyl chloride (101080-63-1)

Guidance literature:

With hydrogenchloride; In benzene; for 4h;

DOI:10.1021/jm00171a031

Reference yield: 61.0%

(2-chloro-4-methoxyphenyl)methanol (334018-24-5) + methanesulfonyl chloride (124-63-0) → 2-chloro-4-methoxybenzyl chloride (101080-63-1)

Guidance literature:

With triethylamine; In dichloromethane; ethyl acetate;

Reference yield:

1-chloro-3-methoxy-benzene (2845-89-8) → 2-chloro-4-methoxybenzyl chloride (101080-63-1)

Guidance literature:

With hydrogenchloride; formaldehyd; zinc(II) chloride; Reagens 4: Essigsaeure;

upstream raw materials:

1-chloro-3-methoxy-benzene

(2-chloro-4-methoxyphenyl)methanol

2-chloro-4-methoxyacetophenone

2-chloro-4-methoxybenzoic acid

Downstream raw materials:

2-chloro-4-methoxyphenylacetonitrile

2-chloro-4-methoxybenzoic acid