HEXAFLUOROLEUCINE

Base Information

• Chemical Name: HEXAFLUOROLEUCINE
• CAS No.: 16198-60-0
• Molecular Formula: C₆H₇F₆NO₂
• Molecular Weight: 239.117
• Hs Code.: 2922499990
• Mol file: 16198-60-0.mol

Synonyms:HEXAFLUOROLEUCINE;2-AMINO-5,5,5-TRIFLUORO-4-TRIFLUOROMETHYL-PENTANOIC ACID;Hexafluoroleucine 97%;Hexafluoroleucine97%;2-Amino-5,5,5-trifluoro-4-trifluoromethyl-pentanoic acid HCl;Hexafluoro-DL-leucine;2-Amino-5,5,5-trifluoro-4-trifluoromethyl pentanoic acid hydrochloride

Chemical Property of HEXAFLUOROLEUCINE

Chemical Property:

• Vapor Pressure: 0.033mmHg at 25°C
• Melting Point: >220°C
• Boiling Point: 224.672°C at 760 mmHg
• Flash Point: 89.679°C
• PSA: 63.32000
• Density: 1.473g/cm³
• LogP: 2.22950

Purity/Quality:

97% ^*data from raw suppliers

Hexafluoro-DL-leucine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HEXAFLUOROLEUCINE

There total 20 articles about HEXAFLUOROLEUCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-2-(benzyloxycarbonylamino)-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid + tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate (478548-21-9) → (S)-5,5,5,5',5',5'-hexafluoroleucine (149560-64-5,16198-60-0)

Guidance literature:

tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h;

(S)-2-(benzyloxycarbonylamino)-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid; With hydrogen; palladium 10% on activated carbon; In methanol;

Reference yield: 92.0%

tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate (478548-21-9) → (S)-5,5,5,5',5',5'-hexafluoroleucine (149560-64-5,16198-60-0)

Guidance literature:

tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h;

With hydrogen; 10percent Pd/C; In methanol; Further stages.;

DOI:10.1021/ol026922j

Reference yield: 49.0%

(S)-2-(benzyloxycarbonylamino)-5,5,5-trifluoro-4-(trifluoromethyl)pentanoic acid → (S)-5,5,5,5',5',5'-hexafluoroleucine (149560-64-5,16198-60-0)

Guidance literature:

With palladium 10% on activated carbon; In methanol; at 20 ℃; for 1h;

upstream raw materials:

tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-(trifluoromethyl)pentanoate

5,5,5-trifluoro-2-oxo-4-trifluoromethyl-pentanoic acid ethyl ester

tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-hydroxy-4-(trifluoromethyl)pentanoate

oxalic acid 3-benzyloxycarbonylamino-3-tert-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester

Downstream raw materials:

(S)-5,5,5,5',5',5'-hexafluoroleucine

(S)-2-{[((9H-fluoren-9-yl)methoxy)carbonyl]amino}-5,5,5-trifluoro-4-(trifluoromethyl)-pentanoic acid