5-(2-(Trimethylsilyl)-1-ethyn-1-yl)-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile

Base Information

Chemical Name:5-(2-(Trimethylsilyl)-1-ethyn-1-yl)-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile
CAS No.:126004-21-5
Molecular Formula:C₂₀H₂₅N₃O₇Si
Molecular Weight:447.52
Hs Code.:
Mol file:126004-21-5.mol

Synonyms:5-(2-(Trimethylsilyl)-1-ethyn-1-yl)-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile;1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-5-[(triMethylsilyl)ethynyl]-1H-iMidazole-4-carbonitrile

Suppliers and Price of 5-(2-(Trimethylsilyl)-1-ethyn-1-yl)-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-(2-(Trimethylsilyl)-1-ethyn-1-yl)-1-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)imidazo-4-carbonitrile
50mg
$ 970.00

American Custom Chemicals Corporation
5-(2-(TRIMETHYLSILYL)-1-ETHYN-1-YL)-1-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)IMIDAZO-4-CARBONITRILE 95.00%
5MG
$ 496.53

Total 5 raw suppliers

Chemical Property of 5-(2-(Trimethylsilyl)-1-ethyn-1-yl)-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile

Chemical Property:

PSA：129.74000
LogP:1.30758
Solubility.:Chloroform, Ethanol

Purity/Quality:

98%Min ^*data from raw suppliers

5-(2-(Trimethylsilyl)-1-ethyn-1-yl)-1-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)imidazo-4-carbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5-(2-(Trimethylsilyl)-1-ethyn-1-yl)-1-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)imidazo-4-carbonitrile (cas# 126004-21-5) is a compound useful in organic synthesis.

Technology Process of 5-(2-(Trimethylsilyl)-1-ethyn-1-yl)-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile

There total 4 articles about 5-(2-(Trimethylsilyl)-1-ethyn-1-yl)-1-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)-imidazo-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 59354-00-6
5-iodo-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carbonitrile

: 1066-54-2
trimethylsilylacetylene

: 126004-21-5
5-<(trimethylsilyl)-1-ethyn-1-yl>-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carbonitrile

Guidance literature:: With bis(benzonitrile)palladium(II) dichloride; triethylamine; In acetonitrile; at 100 ℃; for 5h;
DOI:10.1021/jm00106a045

Reference yield:

: 2627-69-2
AICA riboside

: 126004-21-5
5-<(trimethylsilyl)-1-ethyn-1-yl>-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine, DMAP / acetonitrile / 0.5 h / Ambient temperature

2: 93 percent / pyridine, p-toluenesulfonyl chloride / 2 h / Ambient temperature

3: 70 percent / isoamyl nitrite, diiodomethane / 0.5 h / 100 °C

4: 76 percent / triethylamine, bis(benzonitrile)palladium dichloride / acetonitrile / 5 h / 100 °C

With pyridine; dmap; bis(benzonitrile)palladium(II) dichloride; diiodomethane; triethylamine; p-toluenesulfonyl chloride; isopentyl nitrite; In acetonitrile;
DOI:10.1021/jm00106a045

Reference yield:

: 23192-63-4
5-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carbonitrile

: 126004-21-5
5-<(trimethylsilyl)-1-ethyn-1-yl>-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / isoamyl nitrite, diiodomethane / 0.5 h / 100 °C

2: 76 percent / triethylamine, bis(benzonitrile)palladium dichloride / acetonitrile / 5 h / 100 °C

With bis(benzonitrile)palladium(II) dichloride; diiodomethane; triethylamine; isopentyl nitrite; In acetonitrile;
DOI:10.1021/jm00106a045