5-Formylfuran-2-boronic acid, neopentyl glycol ester

Base Information

• Chemical Name: 5-Formylfuran-2-boronic acid, neopentyl glycol ester
• CAS No.: 1218791-07-1
• Molecular Formula: C10H15BO5
• Molecular Weight: 208.022
• Hs Code.: 2934999090
• Mol file: 1218791-07-1.mol

Synonyms:5-Formylfuran-2-boronic acid, neopentyl glycol ester;5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)furan-2-carbaldehyde

Chemical Property of 5-Formylfuran-2-boronic acid, neopentyl glycol ester

Chemical Property:

• PSA: 48.67000
• LogP: 0.86030
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98.5% ^*data from raw suppliers

5-Formylfuran-2-boronicAcidNeopentylGlycolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Formylfuran-2-boronic Acid Neopentyl Glycol Ester is a useful reagent in lapatinib synthesis.

Technology Process of 5-Formylfuran-2-boronic acid, neopentyl glycol ester

There total 2 articles about 5-Formylfuran-2-boronic acid, neopentyl glycol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5-formylfurane-2-boronic acid (27329-70-0) + 2,2-Dimethyl-1,3-propanediol (126-30-7) → 5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)furan-2-carbaldehyde (1218791-07-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 62.0%

5-bromo-2-furancarboxaldehyde (1899-24-7) + 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane (201733-56-4) → 5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)furan-2-carbaldehyde (1218791-07-1)

Guidance literature:

With N',N''-bisoctadecyl-N-boc-L-glutamic acid diamide; N-ethyl-N,N-diisopropylamine; In water; acetonitrile; at 23 ℃; for 20h; Irradiation;

DOI:10.1021/acs.orglett.1c00451

Reference yield: 89.0%

5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)furan-2-carbaldehyde (1218791-07-1) + N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine (231278-20-9) → 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde (231278-84-5)

Guidance literature:

With palladium 10% on activated carbon; In methanol; for 8h; Reflux;

upstream raw materials:

5-formylfurane-2-boronic acid

2,2-Dimethyl-1,3-propanediol

5-bromo-2-furancarboxaldehyde

2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane

Downstream raw materials:

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

lapatanib

Refernces

• 1、 -. "A METHOD OF PRODUCING THE KEY INTERMEDIATE OF LAPATINIB SYNTHESIS". Page/Page column 8. . Retrieved 2014/05/07.