Benzo[b]thiophene-2-Methanol, α-(1-Methylethyl)-

Base Information

• Chemical Name: Benzo[b]thiophene-2-Methanol, α-(1-Methylethyl)-
• CAS No.: 70445-84-0
• Molecular Formula: C12H14OS
• Molecular Weight: 206.30396
• Hs Code.: 2934999090
• Mol file: 70445-84-0.mol

Synonyms:Benzo[b]thiophene-2-Methanol, α-(1-Methylethyl)-;1-(Benzo[b]thiophen-2-yl)-2-Methylpropan-1-ol

Chemical Property of Benzo[b]thiophene-2-Methanol, α-(1-Methylethyl)-

Chemical Property:

• Boiling Point: 336.3±17.0 °C(Predicted)
• PKA: 13.82±0.20(Predicted)
• PSA: 48.47000
• Density: 1.162±0.06 g/cm3(Predicted)
• LogP: 3.59070

Purity/Quality:

99% ^*data from raw suppliers

1-(Benzo[b]thiophen-2-yl)-2-methylpropan-1-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzo[b]thiophene-2-Methanol, α-(1-Methylethyl)-

There total 3 articles about Benzo[b]thiophene-2-Methanol, α-(1-Methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzo[b]thiophen-2-yl)-(2-methylpropan)-1-one → 1-(benzo[b]thiophen-2-yl)-2-methylpropan-1-ol (70445-84-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 2h;

DOI:10.1021/jacs.9b08748

Reference yield:

isobutyraldehyde (78-84-2) + Benzo[b]thiophene (95-15-8,11095-43-5) → 1-(benzo[b]thiophen-2-yl)-2-methylpropan-1-ol (70445-84-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1002/chem.201604562

Reference yield:

Benzo[b]thiophene (95-15-8,11095-43-5) → 1-(benzo[b]thiophen-2-yl)-2-methylpropan-1-ol (70445-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 3 h / -70 °C / Inert atmosphere

1.2: -70 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; methanol;

DOI:10.1021/jacs.9b08748

upstream raw materials:

isobutyraldehyde

Benzo[b]thiophene