CHEMBRDG-BB 4011737

Base Information

• Chemical Name: CHEMBRDG-BB 4011737
• CAS No.: 213772-01-1
• Molecular Formula: C16H23NO4
• Molecular Weight: 293.363
• Hs Code.: 2924299090
• Mol file: 213772-01-1.mol

Synonyms:CHEMBRDG-BB 4011737;4-[BENZYL(TERT-BUTOXYCARBONYL)AMINO]BUTANOIC ACID;4-[benzyl(tert-butoxycarbonyl)amino]butanoic acid(SALTDATA: FREE)

Chemical Property of CHEMBRDG-BB 4011737

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 446.548°C at 760 mmHg
• Flash Point: 223.864°C
• PSA: 66.84000
• Density: 1.13g/cm³
• LogP: 3.28850

Purity/Quality:

99% ^*data from raw suppliers

4-[Benzyl(tert-butoxycarbonyl)amino]butanoic acid Aldrich ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHEMBRDG-BB 4011737

There total 1 articles about CHEMBRDG-BB 4011737 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-[N-(t-butoxycarbonyl)-N-[(phenyl)methyl]-amino]butan-1-ol (117654-86-1) → 4-{benzyl[(tert-butoxy)carbonyl]amino}butanoic acid (213772-01-1)

Guidance literature:

With pyridinium dichromate; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃;

Reference yield: 52.0%

4-{benzyl[(tert-butoxy)carbonyl]amino}butanoic acid (213772-01-1) + 7-phenoxy-3,4-dihydro-2H-quinoline-4-spiro-5'-1'-(1H-indol-3-ylmethyl)-3'-methyl-imidazolidine-2',4'-dione (620598-20-1) → 7-phenoxy-3,4-dihydro-1-[4-(N-tert-butoxycarbonyl-N-benzylamino)butyryl]-2H-quinoline-4-spiro-5'-1'-(1H-indol-3-ylmethyl)-3'-methyl-imidazolidine-2',4'-dione (620597-77-5)

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2003.08.022

Reference yield:

8-amino quinoline (578-66-5) + 4-{benzyl[(tert-butoxy)carbonyl]amino}butanoic acid (213772-01-1) → tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate (1319744-34-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

DOI:10.1021/ja206002m

upstream raw materials:

4-[N-(t-butoxycarbonyl)-N-[(phenyl)methyl]-amino]butan-1-ol

Downstream raw materials:

7-phenoxy-3,4-dihydro-1-[4-(N-tert-butoxycarbonyl-N-benzylamino)butyryl]-2H-quinoline-4-spiro-5'-1'-(1H-indol-3-ylmethyl)-3'-methyl-imidazolidine-2',4'-dione

tert-butyl benzyl(4-oxo-4-(quinolin-8-ylamino)butyl)-carbamate

tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino)ethyl)-4-(triisopropylsilyl)-3-butynyl)carbamate

tert-butyl benzyl(2-(2-oxo-2-(8-quinolinylamino))ethyl)-3-butynylcarbamate

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