((4S,4aS,8aR)-decahydroisoquinolin-4-yl)(4-(3,4-difluorophenyl)piperazin-1-yl)methanone

Base Information

Chemical Name:((4S,4aS,8aR)-decahydroisoquinolin-4-yl)(4-(3,4-difluorophenyl)piperazin-1-yl)methanone
CAS No.:362611-66-3
Molecular Formula:C20H27F2N3O
Molecular Weight:363.451
Hs Code.:
Mol file:362611-66-3.mol

Synonyms:((4S,4aS,8aR)-decahydroisoquinolin-4-yl)(4-(3,4-difluorophenyl)piperazin-1-yl)methanone

Suppliers and Price of ((4S,4aS,8aR)-decahydroisoquinolin-4-yl)(4-(3,4-difluorophenyl)piperazin-1-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
((4S,4AS,8AR)-DECAHYDROISOQUINOLIN-4-YL)(4-(3,4-DIFLUOROPHENYL)PIPERAZIN-1-YL)METHANONE 95.00%
5MG
$ 501.29

Total 16 raw suppliers

Chemical Property of ((4S,4aS,8aR)-decahydroisoquinolin-4-yl)(4-(3,4-difluorophenyl)piperazin-1-yl)methanone

Chemical Property:

PSA：35.58000
LogP:2.97090

Purity/Quality:

99% ^*data from raw suppliers

((4S,4AS,8AR)-DECAHYDROISOQUINOLIN-4-YL)(4-(3,4-DIFLUOROPHENYL)PIPERAZIN-1-YL)METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ((4S,4aS,8aR)-decahydroisoquinolin-4-yl)(4-(3,4-difluorophenyl)piperazin-1-yl)methanone

There total 7 articles about ((4S,4aS,8aR)-decahydroisoquinolin-4-yl)(4-(3,4-difluorophenyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 646518-39-0
(4S,4aS,8aR)-4-[4-(3,4-Difluoro-phenyl)-piperazine-1-carbonyl]-octahydro-isoquinoline-2-carboxylic acid tert-butyl ester

: 362611-66-3
(4S,4aS,8aR)-decahydro-isoquinoline-4-yl-[4-(3,4-difluorophenyl)-piperzin-1-yl]-methanone

Guidance literature:: With trifluoroacetic acid; In toluene; at 20 ℃; for 3h;
DOI:10.1016/j.tetasy.2003.07.024

Reference yield:

: 348-61-8
1-bromo-3,4-difluorobenzene

: 362611-66-3
(4S,4aS,8aR)-decahydro-isoquinoline-4-yl-[4-(3,4-difluorophenyl)-piperzin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 99 percent / {Pd₂dba2*CHCl₃}; (R)-(+)-BINAP; sodium tert-butoxide / toluene / 2.5 h / 80 - 85 °C

2.1: 99 percent / H₂; HCl / Pd/C / ethanol / 64.5 h / 20 °C / atmospheric pressure

3.1: carbonyldiimidazole / toluene / 2 h / 20 °C

3.2: triethylamine / toluene / 112 h / 20 °C

4.1: trifluoroacteic acid / toluene / 3 h / 20 °C

With hydrogenchloride; {Pd₂dba2*CHCl₃}; hydrogen; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium t-butanolate; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1016/j.tetasy.2003.07.024

Reference yield:

: 646518-38-9
1-benzyl-4-(3,4-difluorophenyl)-piperazine

: 362611-66-3
(4S,4aS,8aR)-decahydro-isoquinoline-4-yl-[4-(3,4-difluorophenyl)-piperzin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / H₂; HCl / Pd/C / ethanol / 64.5 h / 20 °C / atmospheric pressure

2.1: carbonyldiimidazole / toluene / 2 h / 20 °C

2.2: triethylamine / toluene / 112 h / 20 °C

3.1: trifluoroacteic acid / toluene / 3 h / 20 °C

With hydrogenchloride; hydrogen; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1016/j.tetasy.2003.07.024