(4S,4aS,8aR)-4-[4-(3,4-Difluoro-phenyl)-piperazine-1-carbonyl]-octahydro-isoquinoline-2-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(4S,4aS,8aR)-4-[4-(3,4-Difluoro-phenyl)-piperazine-1-carbonyl]-octahydro-isoquinoline-2-carboxylic acid tert-butyl ester
CAS No.:646518-39-0
Molecular Formula:C₂₅H₃₅F₂N₃O₃
Molecular Weight:463.568
Hs Code.:

Synonyms:(4S,4aS,8aR)-4-[4-(3,4-Difluoro-phenyl)-piperazine-1-carbonyl]-octahydro-isoquinoline-2-carboxylic acid tert-butyl ester

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Chemical Property of (4S,4aS,8aR)-4-[4-(3,4-Difluoro-phenyl)-piperazine-1-carbonyl]-octahydro-isoquinoline-2-carboxylic acid tert-butyl ester

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Technology Process of (4S,4aS,8aR)-4-[4-(3,4-Difluoro-phenyl)-piperazine-1-carbonyl]-octahydro-isoquinoline-2-carboxylic acid tert-butyl ester

There total 7 articles about (4S,4aS,8aR)-4-[4-(3,4-Difluoro-phenyl)-piperazine-1-carbonyl]-octahydro-isoquinoline-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348-61-8
1-bromo-3,4-difluorobenzene

: 646518-39-0
(4S,4aS,8aR)-4-[4-(3,4-Difluoro-phenyl)-piperazine-1-carbonyl]-octahydro-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / {Pd₂dba2*CHCl₃}; (R)-(+)-BINAP; sodium tert-butoxide / toluene / 2.5 h / 80 - 85 °C

2.1: 99 percent / H₂; HCl / Pd/C / ethanol / 64.5 h / 20 °C / atmospheric pressure

3.1: carbonyldiimidazole / toluene / 2 h / 20 °C

3.2: triethylamine / toluene / 112 h / 20 °C

With hydrogenchloride; {Pd₂dba2*CHCl₃}; hydrogen; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; 1,1'-carbonyldiimidazole; sodium t-butanolate; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1016/j.tetasy.2003.07.024

Reference yield:

: 646518-38-9
1-benzyl-4-(3,4-difluorophenyl)-piperazine

: 646518-39-0
(4S,4aS,8aR)-4-[4-(3,4-Difluoro-phenyl)-piperazine-1-carbonyl]-octahydro-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / H₂; HCl / Pd/C / ethanol / 64.5 h / 20 °C / atmospheric pressure

2.1: carbonyldiimidazole / toluene / 2 h / 20 °C

2.2: triethylamine / toluene / 112 h / 20 °C

With hydrogenchloride; hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1016/j.tetasy.2003.07.024

Reference yield:

: 255893-57-3
1-(3,4-difluoro-phenyl)-piperazine

: 362611-65-2
(4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester

: 646518-39-0
(4S,4aS,8aR)-4-[4-(3,4-Difluoro-phenyl)-piperazine-1-carbonyl]-octahydro-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: (4S,4aS,8aR)-octahydro-isoquinoline-2,4-dicarboxylic acid 2-tert-butyl ester; With 1,1'-carbonyldiimidazole; In toluene; at 20 ℃; for 2h;

1-(3,4-difluoro-phenyl)-piperazine; With triethylamine; In toluene; at 20 ℃; for 112h;
DOI:10.1016/j.tetasy.2003.07.024