ethyl 2-acetoxymethyl-4-(2-chlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

Base Information

Chemical Name:ethyl 2-acetoxymethyl-4-(2-chlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate
CAS No.:144686-65-7
Molecular Formula:C₂₀H₂₂ClNO₆
Molecular Weight:407.851
Hs Code.:
Mol file:144686-65-7.mol

Synonyms:ethyl 2-acetoxymethyl-4-(2-chlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

Suppliers and Price of ethyl 2-acetoxymethyl-4-(2-chlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-acetoxymethyl-4-(2-chlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of ethyl 2-acetoxymethyl-4-(2-chlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

There total 5 articles about ethyl 2-acetoxymethyl-4-(2-chlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 35594-15-1
ethyl 4-acetoxyacetoacetate

: 89-98-5
2-chloro-benzaldehyde

: 21731-17-9
methyl 3-aminocrotonate

: 144686-65-7
ethyl 2-acetoxymethyl-4-(2-chlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

Guidance literature:: In isopropyl alcohol; for 16h; Reflux;

Reference yield: 33.0%

: 35594-15-1
ethyl 4-acetoxyacetoacetate

: 89-98-5
2-chloro-benzaldehyde

: 14205-39-1
methyl 3-aminocrotonate

: 144686-65-7
ethyl 2-acetoxymethyl-4-(2-chlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

Guidance literature:: In isopropyl alcohol; Heating;
DOI:10.1248/cpb.45.869

Reference yield:

: 141-97-9
ethyl acetoacetate

: 144686-65-7
ethyl 2-acetoxymethyl-4-(2-chlorophenyl)-1,4-dihydro-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: bromine; acetic acid / 1.17 h / 0 °C

2: N,N-dimethyl-formamide / 16 h / 80 °C

3: isopropyl alcohol / 16 h / Reflux

With bromine; acetic acid; In N,N-dimethyl-formamide; isopropyl alcohol;