ethyl 3-(dibenzylaMino)-2,2-difluoropropanoate

Base Information

• Chemical Name: ethyl 3-(dibenzylaMino)-2,2-difluoropropanoate
• CAS No.: 541547-36-8
• Molecular Formula: C19H21F2NO2
• Molecular Weight: 333.378
• Mol file: 541547-36-8.mol

Synonyms:ethyl 3-(dibenzylaMino)-2,2-difluoropropanoate

Chemical Property of ethyl 3-(dibenzylaMino)-2,2-difluoropropanoate

Chemical Property:

• Boiling Point: 401.3±45.0 °C(Predicted)
• PKA: 3.43±0.50(Predicted)
• PSA: 29.54000
• Density: 1.160±0.06 g/cm3(Predicted)
• LogP: 3.88720
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99.3% ^*data from raw suppliers

Ethyl3-(dibenzylamino)-2,2-difluoropropanoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3-(dibenzylaMino)-2,2-difluoropropanoate

There total 5 articles about ethyl 3-(dibenzylaMino)-2,2-difluoropropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Ethyl bromodifluoroacetate (667-27-6) + 2H-1,2,3-benzotriazol-2-yl-N,N-dibenzylmethanamine (121238-95-7) + N-((1 H-benzo[d][1,2,3]triazol-1-yl)methyl)-N-benzyl-1-phenylmethanamine (57684-32-9) → ethyl N,N-(dibenzyl)-2,2-difluoro-3,3-aminopropanoate (541547-36-8)

Guidance literature:

Ethyl bromodifluoroacetate; With chloro-trimethyl-silane; zinc; In tetrahydrofuran; at 20 ℃; for 0.166667h;

2H-1,2,3-benzotriazol-2-yl-N,N-dibenzylmethanamine; N-((1 H-benzo[d][1,2,3]triazol-1-yl)methyl)-N-benzyl-1-phenylmethanamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield: 95.0%

Ethyl bromodifluoroacetate (667-27-6) + N-((1 H-benzo[d][1,2,3]triazol-1-yl)methyl)-N-benzyl-1-phenylmethanamine (57684-32-9) → ethyl N,N-(dibenzyl)-2,2-difluoro-3,3-aminopropanoate (541547-36-8)

Guidance literature:

Ethyl bromodifluoroacetate; With chloro-trimethyl-silane; zinc; In tetrahydrofuran; for 0.25h;

N-((1 H-benzo[d][1,2,3]triazol-1-yl)methyl)-N-benzyl-1-phenylmethanamine; In tetrahydrofuran; for 2h;

Reference yield: 50.0%

ethyl dibromofluoroacetate (565-53-7) + N-((1 H-benzo[d][1,2,3]triazol-1-yl)methyl)-N-benzyl-1-phenylmethanamine (57684-32-9) → ethyl N,N-(dibenzyl)-2,2-difluoro-3,3-aminopropanoate (541547-36-8)

Guidance literature:

ethyl dibromofluoroacetate; With chloro-trimethyl-silane; zinc; In tetrahydrofuran; for 1.33333h; Inert atmosphere;

N-((1 H-benzo[d][1,2,3]triazol-1-yl)methyl)-N-benzyl-1-phenylmethanamine; In tetrahydrofuran; at 20 ℃; Cooling with ice;

upstream raw materials:

Ethyl bromodifluoroacetate

N-((1 H-benzo[d][1,2,3]triazol-1-yl)methyl)-N-benzyl-1-phenylmethanamine

ethyl dibromofluoroacetate

dibenzylamine

Downstream raw materials:

4-(dibenzylamino)-3,3-difluoro-2-methylbutan-2-ol

ethyl N-tert-butoxycarbonyl-3-amino-2,2-difluoropropanoate

3-Amino-2,2-difluoro-propionic acid ethyl ester

3-(dibenzylamino)-2,2-difluoropropan-1-ol

Refernces

• 1、 -. "NOVEL COMPOUNDS FOR THE TREATMENT OF PARASITIC INFECTIONS". . . Retrieved 2019/08/14.
• 2、 -. "Heterocyclic compound". Paragraph 0334; 0335. . Retrieved 2017/09/28.