Methyl 4-aMino-3,5-difluorobenzoate

Base Information

• Chemical Name: Methyl 4-aMino-3,5-difluorobenzoate
• CAS No.: 1162676-00-7
• Molecular Formula: C8H7F2NO2
• Molecular Weight: 187.146
• Hs Code.: 2922499990
• Mol file: 1162676-00-7.mol

Synonyms:Methyl 4-aMino-3,5-difluorobenzoate

Chemical Property of Methyl 4-aMino-3,5-difluorobenzoate

Chemical Property:

• Boiling Point: 286.0±40.0 °C(Predicted)
• PKA: -0.32±0.10(Predicted)
• PSA: 52.32000
• Density: 1.355±0.06 g/cm3(Predicted)
• LogP: 1.91480
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

Methyl4-Amino-3,5-difluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-aMino-3,5-difluorobenzoate

There total 1 articles about Methyl 4-aMino-3,5-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

methanol (67-56-1) + 4‐amino-3,5-difluorobenzoic acid (500577-99-1) → methyl 4-amino-3,5-difluorobenzoate (1162676-00-7)

Guidance literature:

With sulfuric acid; for 14h; Reflux;

Reference yield: 100.0%

methyl 4-amino-3,5-difluorobenzoate (1162676-00-7) → methyl 3,5-difluoro-4-nitrosobenzoate

Guidance literature:

With potassium peroxymonosulfate sulfate; In dichloromethane; water; at 20 ℃; for 24h;

DOI:10.1021/jacs.0c02949

Reference yield:

methyl 4-amino-3,5-difluorobenzoate (1162676-00-7) + (S)-tert-butyl 1-(1H-imidazol-1-yl)-1-oxo-5-ureidopentan-2-ylcarbamate → (S)-4-(2-(tert-butoxycarbonylamino)-5-ureidopentanamido)-3,5-difluorobenzoic acid

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 23 ℃; for 20h;

upstream raw materials:

methanol

4‐amino-3,5-difluorobenzoic acid

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