6-(2-(4-methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine

Base Information

Chemical Name:6-(2-(4-methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine
CAS No.:1003312-16-0
Molecular Formula:C₂₂H₂₀N₄O₂
Molecular Weight:372.426
Hs Code.:
Mol file:1003312-16-0.mol

Synonyms:6-(2-(4-methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine

Suppliers and Price of 6-(2-(4-methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 6-(2-(4-methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-(2-(4-methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine

There total 4 articles about 6-(2-(4-methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 882670-92-0
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-quinazolin-2-amine

: 1003312-15-9
2-(4-methoxybenzyloxy)-3-bromo-4-methylpyridine

: 1003312-16-0
6-(2-(4-methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In water; isopropyl alcohol; at 75 ℃; for 4h;
DOI:10.1021/jm800188g

Reference yield:

: 55404-31-4
3-bromo-2-chloro-4-methylpyridine

: 1003312-16-0
6-(2-(4-methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 5 h / 75 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / acetonitrile; water / 20 h / 82 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; potassium carbonate; In tetrahydrofuran; water; acetonitrile;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1003312-16-0
6-(2-(4-methoxybenzyloxy)-4-methylpyridin-3-yl)quinazolin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 5 h / 75 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / acetonitrile; water / 20 h / 82 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; potassium carbonate; In tetrahydrofuran; water; acetonitrile;