4-Ethoxyphenylphosphonic acid

Base Information

• Chemical Name: 4-Ethoxyphenylphosphonic acid
• CAS No.: 69387-02-6
• Molecular Formula: C8H11O4P
• Molecular Weight: 202.14
• European Community (EC) Number: 653-983-9
• Mol file: 69387-02-6.mol

Synonyms:4-ethoxyphenylphosphonic acid;(4-ethoxyphenyl)phosphonic Acid;SCHEMBL7213299;MFCD00019973;AKOS017343425

Chemical Property of 4-Ethoxyphenylphosphonic acid

Chemical Property:

• PKA: pK1:2.06;pK2:7.28 (25°C)
• PSA: 76.57000
• LogP: 0.88830
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 202.03949583
• Heavy Atom Count: 13
• Complexity: 192

Purity/Quality:

97% ^*data from raw suppliers

4-ETHOXYPHENYLPHOSPHONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)P(=O)(O)O

Technology Process of 4-Ethoxyphenylphosphonic acid

There total 5 articles about 4-Ethoxyphenylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phenetole (103-73-1) → 4-ethoxyphenylphosphonic acid (69387-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: P₂S₅

2: H₂O

With tetraphosphorus decasulfide; water;

DOI:10.1021/ja01600a058

Reference yield:

2,4-bis(4-ethoxycarbonylphenyl)-2,4-dithioxo-1,3,2λ5,4λ5-dithiadiphosphetane (30043-13-1) → 4-ethoxyphenylphosphonic acid (69387-02-6)

Guidance literature:

With water;

DOI:10.1021/ja01600a058

Reference yield:

→ bis-(4-ethoxy-phenyl)-phosphinic acid (109730-12-3) + 4-ethoxyphenylphosphonic acid (69387-02-6)

Guidance literature:

With copper(l) chloride; phosphorus trichloride;

DOI:10.1021/jo01132a003

upstream raw materials:

dichloro-(4-ethoxyphenyl)phosphine

2,4-bis(4-ethoxycarbonylphenyl)-2,4-dithioxo-1,3,2λ⁵,4λ⁵-dithiadiphosphetane

Phenetole

Hg(C₆H₄-4-OC₂H₅)2

Downstream raw materials:

methyl (p-ethoxyphenyl)phosphonic acid