Phosphonic acid, (4-ethoxyphenyl)-, monomethyl ester (9CI)

Base Information

Chemical Name:Phosphonic acid, (4-ethoxyphenyl)-, monomethyl ester (9CI)
CAS No.:131066-54-1
Molecular Formula:C9H13 O4 P
Molecular Weight:216.170881
Hs Code.:
Mol file:131066-54-1.mol

Synonyms:Phosphonic acid, (4-ethoxyphenyl)-, monomethyl ester (9CI)

Suppliers and Price of Phosphonic acid, (4-ethoxyphenyl)-, monomethyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Phosphonic acid, (4-ethoxyphenyl)-, monomethyl ester (9CI)

Chemical Property:

PSA：65.57000
LogP:1.54240

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Phosphonic acid, (4-ethoxyphenyl)-, monomethyl ester (9CI)

There total 1 articles about Phosphonic acid, (4-ethoxyphenyl)-, monomethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69387-02-6
4-ethoxyphenylphosphonic acid

: 149-73-5
trimethyl orthoformate

: 131066-54-1
methyl (p-ethoxyphenyl)phosphonic acid

Guidance literature:: With sodium hydroxide; Yield given. Multistep reaction; 1.) 90 deg C, 20 h, 2.) MeOH, RT, 80 h;
DOI:10.1021/ja00001a043

Reference yield:

: 131066-54-1
methyl (p-ethoxyphenyl)phosphonic acid

: (S)-2-{(S)-2-[(4-Ethoxy-phenyl)-hydroxy-phosphinoyloxy]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: bis(2-oxo-3-oxazolidinyl)phosphonic chloride (BOP-Cl), triethylamine / acetonitrile / 16 h / Heating

2: 1 N aq. LiOH / acetonitrile / 80 h / Ambient temperature

With lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In acetonitrile;
DOI:10.1021/ja00001a043

Reference yield:

: 131066-51-8
N-<2(S)-hydroxy-4-methylpentanoyl>-L-leucine methyl ester

: 131066-54-1
methyl (p-ethoxyphenyl)phosphonic acid

: (S)-2-{(S)-2-[(4-Ethoxy-phenyl)-methoxy-phosphinoyloxy]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid methyl ester

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In acetonitrile; for 16h; Heating;
DOI:10.1021/ja00001a043