DL-TROPIC ACID

Base Information

• Chemical Name: DL-TROPIC ACID
• CAS No.: 28845-94-5
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.177
• Mol file: 28845-94-5.mol

Synonyms:ALPHA-PHENYLHYDRACRYLIC ACID;2-PHENYLHYDROACRYLIC ACID;2-PHENYLHYDRACRYLIC ACID;DL-TROPIC ACID;DL-3-HYDROXY-2-PHENYLPROPIONIC ACID;DL-A-PHENYLHYDRACRYLIC ACID;A-PHENYL-B-HYDROXYPROPIONIC ACID;TROPIC ACID, DL-

Chemical Property of DL-TROPIC ACID

Chemical Property:

• Melting Point: 116-118 °C(lit.)
• PSA: 57.53000
• LogP: 0.84710
• Solubility.: methanol: 0.1 g/mL, clear

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-TROPIC ACID

There total 100 articles about DL-TROPIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(+)-3-acetoxy-2-phenylpropionic acid (131682-38-7) → (S)-tropic acid (16202-15-6,28845-94-5) + (+)-(R)-tropic acid (17126-67-9,28845-94-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; for 0.166667h;

DOI:10.1016/S0040-4020(01)87892-3

Reference yield: 90.0%

(+)-3-acetoxy-2-phenylpropionic acid (131682-38-7) → (S)-tropic acid (16202-15-6,28845-94-5) + (+)-(R)-tropic acid (17126-67-9,28845-94-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; for 0.166667h;

DOI:10.1016/S0040-4020(01)87892-3

Reference yield: 43.0%

tropic acid butyl ester → (S)-tropic acid butyl ester + (S)-tropic acid (16202-15-6,28845-94-5) + (+)-(R)-tropic acid (17126-67-9,28845-94-5)

Guidance literature:

With Candida antarctica lipase B; sodium hydroxide; phosphate buffer; at 25 ℃; for 18h; pH=7;

DOI:10.1016/j.tetasy.2005.10.032

upstream raw materials:

phenylacetic acid

isopropylmagnesium chloride

formaldehyd

ethyl 2-phenyl-2-bromoacetate

Downstream raw materials:

3-chloro-2-phenyl-propionic acid

methyl tropate

atropine

tropic acid ethyl ester