2-(benzyloxy)-5-nitrobenzaldehyde

Base Information

• Chemical Name: 2-(benzyloxy)-5-nitrobenzaldehyde
• CAS No.: 204130-60-9
• Molecular Formula: C14H11NO4
• Molecular Weight: 257.246
• Mol file: 204130-60-9.mol

Synonyms:2-(benzyloxy)-5-nitrobenzaldehyde

Chemical Property of 2-(benzyloxy)-5-nitrobenzaldehyde

Chemical Property:

• PSA: 72.12000
• LogP: 3.50950

Purity/Quality:

99% ^*data from raw suppliers

2-(Benzyloxy)-5-nitrobenzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(benzyloxy)-5-nitrobenzaldehyde

There total 3 articles about 2-(benzyloxy)-5-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyl bromide (100-39-0) + 5-Nitrosalicylaldehyde (97-51-8) → 2-(benzyloxy)-5-nitrobenzaldehyde (204130-60-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3.5h;

DOI:10.1021/ja5020053

Reference yield: 86.0%

5-Nitrosalicylaldehyde (97-51-8) → 2-(benzyloxy)-5-nitrobenzaldehyde (204130-60-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 7h;

DOI:10.1039/C6RA24651F

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 2-(benzyloxy)-5-nitrobenzaldehyde (204130-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: magnesium methanolate / methanol

2: potassium carbonate / acetonitrile / 80 °C

With potassium carbonate; magnesium methanolate; In methanol; acetonitrile;

DOI:10.1016/j.ejmech.2013.11.035

upstream raw materials:

benzyl bromide

5-Nitrosalicylaldehyde

4-nitro-phenol

Downstream raw materials:

methyl 3-(2-benzyloxy-5-nitro)phenyl-3-hydoxy-2-methylenepropanoate

Refernces

• 1、 Chauhan, Divya,George, Ginson,Sridhar,Bhatia, Rohit,Paul, Atish T.,Monga, Vikramdeep. "Design, synthesis, biological evaluation, and molecular modeling studies of rhodanine derivatives as pancreatic lipase inhibitors". . . Retrieved 2019/08/21.
• 2、 -. "N-NITROSOANILINE DERIVATIVE, NO GENERATOR USING THE SAME, AND GENERATION METHOD OF NO". Paragraph 0018-0020. . Retrieved 2016/10/10.