1-Methyl-3-pyrrolidinaMine 2HCl

Base Information

• Chemical Name: 1-Methyl-3-pyrrolidinaMine 2HCl
• CAS No.: 1209287-84-2
• Molecular Formula: C5H14Cl2N2
• Molecular Weight: 173.08406
• Mol file: 1209287-84-2.mol

Synonyms:1-Methyl-3-pyrrolidinaMine 2HCl

Chemical Property of 1-Methyl-3-pyrrolidinaMine 2HCl

Chemical Property:

• PSA: 29.26000
• LogP: 1.89140
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Methylpyrrolidin-3-amineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-3-pyrrolidinaMine 2HCl

There total 6 articles about 1-Methyl-3-pyrrolidinaMine 2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-N-tert-butoxycarbonyl-3-(R)-amino-1-methylpyrrolidine (346691-01-8) → 1-methyl-3-(R)-aminopyrrolidine dihydrochloride (1209287-84-2,403712-80-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.333333h;

DOI:10.1021/jm010329a

Reference yield:

(S)-tert-butyl 1-methylpyrrolidin-3-ylcarbamate (852874-60-3) → (S)-1-methylpyrrolidine-3-amine hydrochloride (852874-61-4,1209287-84-2,403712-80-1)

Guidance literature:

(S)-tert-butyl 1-methylpyrrolidin-3-ylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With hydrogenchloride; In methanol; diethyl ether;

Reference yield:

tert-butyl (1-methylpyrrolidin-3-yl)carbamate (748184-01-2) → 1-methylpyrrolidin-3-ylamino hydrochloride (1209287-84-2,403712-80-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.75h;

upstream raw materials:

3-N-tert-butoxycarbonyl-3-(R)-amino-1-methylpyrrolidine

(S)-tert-butyl 1-methylpyrrolidin-3-ylcarbamate

tert-butyl (1-methylpyrrolidin-3-yl)carbamate

Downstream raw materials:

4-amino-2,5-difluoro-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide

benzyl 4-(2-amino-6-(1-methylpyrrolidin-(3R)-3-ylamino)pyrimidin-4-yl)piperidin-1-carboxylate

2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-N-((S)-1-methylpyrrolidin-3-yl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxamide

2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-N-((R)-1-methylpyrrolidin-3-yl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxamide