852874-60-3

Basic information

• Product Name: S-1-Methyl-3-(Boc-aMino)pyrrolidine
• Synonyms: S-1-Methyl-3-(Boc-aMino)pyrrolidine;N-[(3S)-1-Methyl-3-pyrrolidinyl]carbamic Acid tert-But yl Ester;(S)-tert-Butyl 1-methylpyrrolidin-3-ylcarbamate
• CAS NO: 852874-60-3
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.278
• Mol File: 852874-60-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: S-1-Methyl-3-(Boc-aMino)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: S-1-Methyl-3-(Boc-aMino)pyrrolidine(852874-60-3)
• EPA Substance Registry System: S-1-Methyl-3-(Boc-aMino)pyrrolidine(852874-60-3)

Safety Data

• Hazardous Substances Data: 852874-60-3(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 122536-76-9 3(S)-(tert-butoxycarbonylamino)pyrrolidine 
• 130622-08-1 dimethyl N-tert-butoxycarbonyl-L-aspartate 
• 74-89-5 methylamine 
• 176970-13-1 [(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate] 
• 128427-10-1 (S)-2-(tert-butoxycarbonylamino)-1,4-butanediol 

Downstream Products

• 1246299-46-6 (S)-N-benzyl-N-methyl-N-(1-methylpyrrolidin-3-yl)amine 
• 1395408-48-6 (S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-methylpyrrolidine-3-yl)thiourea 
• 1395408-70-4 (S)-1-(1-methylpiperidine-3-yl)-3-phenylselenourea 
• 1359969-61-1 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-N-((S)-1-methylpyrrolidin-3-yl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxamide 
• 1209287-84-2 C₅H₁₂N₂*(x)ClH 
• 852874-61-4 (S)-1-methylpyrrolidine-3-amine hydrochloride 

Relevant articles and documents

Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor

Bromodomain and PHD finger containing protein transcription factor (BPTF) is an epigenetic protein involved in chromatin remodelling and is a potential anticancer target. The BPTF bromodomain has one reported small molecule inhibitor (AU1, rac-1). Here, advances made on the structure-activity relationship of a BPTF bromodomain ligand are reported using a combination of experimental and molecular dynamics simulations leading to the active enatiomer (S)-1. Additionally, a ligand deconstruction analysis was conducted to characterize important pharmacophores for engaging the BPTF bromodomain. These studies have been enabled by a protein-based fluorine NMR approach, highlighting the versatility of the method for selectivity, ligand deconstruction, and ligand binding. To enable future analysis of biological activity, cell growth analyses in a panel of cancer cell lines were carried out using CRISPR-Cas9 and (S)-1 to identify cell-based model systems that are sensitive to BPTF inhibition.

Fused Ring Compound For Use As Mineralocorticoid Receptor Antagonist

The present invention belongs to the technical field of medicine, relating in particular to: a fused ring compound as represented by Formula (I) for use as a mineralocorticoid receptor antagonist, a pharmaceutically acceptable salt thereof, and an isomer thereof; a preparation method for these compounds; a pharmaceutical preparation containing these compounds; and an application of these compounds, the pharmaceutically acceptable salt thereof, or the isomers thereof in the preparation of medicants for the treatment and/or prevention of kidney injury, cardiovascular diseases such as hypertension, and/or endocrine disease. The definitions of X, Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4, Cy and n are as presented in the description.

Chiral 3-aminopyrrolidines as a rigid diamino scaffold for organocatalysis and organometallic chemistry

Over 20 new and easily prepared diamines were screened for the asymmetric Morita-Baylis-Hillman reaction. Chiral non-racemic 3-(N,N-dimethylamino)-1- methylpyrrolidine was found to promote efficiently the reaction of methyl vinyl ketone and substituted benzaldehydes. Enantiomeric excesses up to 73% were reached with electron-deficient benzaldehyde derivatives. After a simple deprotonation, one of these diamines was transformed into a chiral mixed aggregate for the enantioselective synthesis of (R)-1-o-tolylethanol with 76% ee.