3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester

Base Information

• Chemical Name: 3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester
• CAS No.: 1027995-71-6
• Molecular Formula: C15H21NO3
• Molecular Weight: 263.337
• Mol file: 1027995-71-6.mol

Synonyms:3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester;tert-butyl 3-(benzyloxy)azetidine-1-carboxylate

Chemical Property of 3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester

Chemical Property:

• Boiling Point: 350.8±35.0 °C(Predicted)
• PKA: -2.84±0.40(Predicted)
• PSA: 38.77000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 2.76040

Purity/Quality:

97% ^*data from raw suppliers

3-BENZYLOXY AZETIDINE-1-CARBOXYLIC ACID-TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester

There total 3 articles about 3-Benzyloxy-azetidine-1-carboxylicacidtert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.9%

benzyl bromide (100-39-0) + tert-butyl 3-hydroxyazetidine-1-carboxylate (141699-55-0) → 3-(benzyloxy)azetidine-1-carboxylic acid tert-butyl ester (1027995-71-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 16h;

Reference yield: 39.0%

benzyl chloride (100-44-7) + tert-butyl 3-hydroxyazetidine-1-carboxylate (141699-55-0) → 3-(benzyloxy)azetidine-1-carboxylic acid tert-butyl ester (1027995-71-6)

Guidance literature:

tert-butyl 3-hydroxyazetidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.333333h;

benzyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 2h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 3-(benzyloxy)azetidine-1-carboxylic acid tert-butyl ester (1027995-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 2 h / 0 - 20 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

benzyl chloride

tert-butyl 3-hydroxyazetidine-1-carboxylate

benzyl bromide

di-tert-butyl dicarbonate

Downstream raw materials:

3-(benzyloxy)azetidine hydrochloride

N-(4-(3-(benzyloxy)azetidine-1-carbonyl)phenyl)quinoline-8-sulfonamide

3-(benzyloxy)azetidine