(1S,2S)-(+)-[N,N'-Bis(4-bromobenzyl)-1,2-cyclohexanediamino][(2E)-2-buten-1-yl]chlorosilane, min. 98%

Base Information

• Chemical Name: (1S,2S)-(+)-[N,N'-Bis(4-bromobenzyl)-1,2-cyclohexanediamino][(2E)-2-buten-1-yl]chlorosilane, min. 98%
• CAS No.: 1072220-37-1
• Molecular Formula: C24H29Br2ClN2Si
• Molecular Weight: 568.854
• Mol file: 1072220-37-1.mol

Synonyms:(1S,2S)-(+)-[N,N'-Bis(4-bromobenzyl)-1,2-cyclohexanediamino][(2E)-2-buten-1-yl]chlorosilane, min. 98%;(S,S)-1,3-Bis(4-broMobenzyl)-2-chlorooctahydro-2-(2E)-crotyl-1H-1,3,2-benzodiazasilole;(3aS,7aS)-1,3-Bis[(4-bromophenyl)methyl]-2-(2E)-2-buten-1-yl-2-chlorooctahydro-1H-1,3,2-benzodiazasilole

Chemical Property of (1S,2S)-(+)-[N,N'-Bis(4-bromobenzyl)-1,2-cyclohexanediamino][(2E)-2-buten-1-yl]chlorosilane, min. 98%

Chemical Property:

• Melting Point: 92-96°C
• PSA: 6.48000
• LogP: 7.47020
• Sensitive.: moisture sensitive

Purity/Quality:

98% ^*data from raw suppliers

(1S,2S)-(+)-[N,N'-Bis(4-bromobenzyl)-1,2-cyclohexanediamino][(2E)-2-buten-1-yl]chlorosilane, min. 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,2S)-(+)-[N,N'-Bis(4-bromobenzyl)-1,2-cyclohexanediamino][(2E)-2-buten-1-yl]chlorosilane, min. 98%

There total 4 articles about (1S,2S)-(+)-[N,N'-Bis(4-bromobenzyl)-1,2-cyclohexanediamino][(2E)-2-buten-1-yl]chlorosilane, min. 98% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(1S,2S)-N,N'-bis-(4-bromo-benzyl)-cyclohexane-1,2-diamine + (E)-crotyltrichlorosilane (18147-55-2,49749-84-0,52885-13-9) → (3aS,7aS)-1,3-bis(4-bromobenzyl)-2-((E)-but-2-enyl)-2-chloro-octahydro-1H-benzo[d]-[1,3,2]-diazasilole (1072220-37-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 12h; Cooling;

DOI:10.1016/j.tet.2011.11.025

Reference yield:

C20H20Br2N2 (147054-78-2) → (3aS,7aS)-1,3-bis(4-bromobenzyl)-2-((E)-but-2-enyl)-2-chloro-octahydro-1H-benzo[d]-[1,3,2]-diazasilole (1072220-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0 °C / Inert atmosphere; Reflux

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 20 °C / Cooling

With sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane;

DOI:10.1016/j.tet.2011.11.025

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → (3aS,7aS)-1,3-bis(4-bromobenzyl)-2-((E)-but-2-enyl)-2-chloro-octahydro-1H-benzo[d]-[1,3,2]-diazasilole (1072220-37-1)

Guidance literature:

Multi-step reaction with 3 steps

1: methanesulfonic acid; potassium carbonate / ethanol; dichloromethane; water / 13 h / 20 °C / Inert atmosphere; Reflux

2: sodium tetrahydroborate / methanol / 0 °C / Inert atmosphere; Reflux

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 20 °C / Cooling

With sodium tetrahydroborate; methanesulfonic acid; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; ethanol; dichloromethane; water;

DOI:10.1016/j.tet.2011.11.025

upstream raw materials:

(E)-crotyltrichlorosilane

C₂₀H₂₀Br₂N₂

4-bromo-benzaldehyde

(S,S)-1,2-diammoniumcyclohexane-D-tartrate

Downstream raw materials:

C₂₄H₃₄O₂Si

C₂₀H₃₀O₄S

(1E)-(3S,4R)-4-methyl-1-phenyl-1,5-hexadien-3-ol

(-)-(3S,4R)-4-methyl-1-phenylhex-5-en-3-ol