(1R,2R)-1-(2,4-bis(benzyloxy)-6-chloro-5-phenylpyridin-3-yl)-2-methylbut-3-en-1-ol

Base Information

Chemical Name:(1R,2R)-1-(2,4-bis(benzyloxy)-6-chloro-5-phenylpyridin-3-yl)-2-methylbut-3-en-1-ol
CAS No.:1353390-17-6
Molecular Formula:C₃₀H₂₈ClNO₃
Molecular Weight:486.01
Hs Code.:

Synonyms:(1R,2R)-1-(2,4-bis(benzyloxy)-6-chloro-5-phenylpyridin-3-yl)-2-methylbut-3-en-1-ol

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Chemical Property of (1R,2R)-1-(2,4-bis(benzyloxy)-6-chloro-5-phenylpyridin-3-yl)-2-methylbut-3-en-1-ol

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Technology Process of (1R,2R)-1-(2,4-bis(benzyloxy)-6-chloro-5-phenylpyridin-3-yl)-2-methylbut-3-en-1-ol

There total 12 articles about (1R,2R)-1-(2,4-bis(benzyloxy)-6-chloro-5-phenylpyridin-3-yl)-2-methylbut-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 920744-21-4
2,4-bis(benzyloxy)-6-chloro-5-phenylpyridine-3-carbaldehyde

: 1072220-37-1
(3aS,7aS)-1,3-bis(4-bromobenzyl)-2-((E)-but-2-enyl)-2-chloro-octahydro-1H-benzo[d]-[1,3,2]-diazasilole

: 1353390-17-6
(1R,2R)-1-(2,4-bis(benzyloxy)-6-chloro-5-phenylpyridin-3-yl)-2-methylbut-3-en-1-ol

Guidance literature:: 2,4-bis(benzyloxy)-6-chloro-5-phenylpyridine-3-carbaldehyde; (3aS,7aS)-1,3-bis(4-bromobenzyl)-2-((E)-but-2-enyl)-2-chloro-octahydro-1H-benzo[d]-[1,3,2]-diazasilole; In dichloromethane; at 0 ℃; for 48h; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.tet.2011.11.025

Reference yield: 47.0%

: Tebbe's reagent

: 1353390-18-7
(2S,3R)-3-(2,4-bis(benzyloxy)-6-chloro-5-phenylpyridin-3-yl)-3-hydroxy-2-methylpropanal

: 1353390-17-6
(1R,2R)-1-(2,4-bis(benzyloxy)-6-chloro-5-phenylpyridin-3-yl)-2-methylbut-3-en-1-ol

Guidance literature:: In tetrahydrofuran; toluene; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2011.11.025

Reference yield:

: 920744-21-4
2,4-bis(benzyloxy)-6-chloro-5-phenylpyridine-3-carbaldehyde

: C₂₀H₂₇BO₂

: 1353390-17-6
(1R,2R)-1-(2,4-bis(benzyloxy)-6-chloro-5-phenylpyridin-3-yl)-2-methylbut-3-en-1-ol

: (1S,2S)-1-(2,4-bis(benzyloxy)-6-chloro-5-phenylpyridin-3-yl)-2-methylbut-3-en-1-ol

Guidance literature:: 2,4-bis(benzyloxy)-6-chloro-5-phenylpyridine-3-carbaldehyde; C₂₀H₂₇BO₂; With scandium tris(trifluoromethanesulfonate); In dichloromethane; at -78 ℃; for 16h; Inert atmosphere;

With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 0.5h; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water; toluene; at -78 - 20 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.tet.2011.11.025