Dasatinib iMpurity

Base Information

Chemical Name:Dasatinib iMpurity
CAS No.:1184919-23-0
Molecular Formula:
Molecular Weight:453.56
Hs Code.:
Mol file:1184919-23-0.mol

Synonyms:Dasatinib iMpurity;Deschlorodasatinib

Suppliers and Price of Dasatinib iMpurity

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Deschlorodasatinib
25mg
$ 460.00

TRC
DeschloroDasatinib
25mg
$ 1390.00

Total 12 raw suppliers

Chemical Property of Dasatinib iMpurity

Chemical Property:

PKA:11.87±0.70(Predicted)
Density:1.356±0.06 g/cm3(Predicted)
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Ethanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

Deschlorodasatinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Deschloro-dasatinib, is the impurity of Dasatinib (D193600), which is a new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. It is also an Antineoplastic. Deschloro-dasatinib, is the impurity of Dasatinib (D193600), which is a new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. It is also an Antineoplastic. It is a COVID19-related research product.

Technology Process of Dasatinib iMpurity

There total 4 articles about Dasatinib iMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.9%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: N-(2-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)-amino]-5-thiazolecarboxamide

: 1184919-23-0
N-(2-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 4h;
DOI:10.1002/ardp.201600010

Reference yield:

: 1323138-76-6
(E)-N-(2-methylphenyl)-3-ethoxyacrylamide

: 1184919-23-0
N-(2-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; water / 1,4-dioxane / 1 h / 0 - 10 °C

1.2: 2 h / 70 °C

2.1: sodium t-butanolate / tetrahydrofuran / 2.5 h / -15 °C

3.1: triethylamine / N,N-dimethyl-formamide / 4 h / 80 °C

With N-Bromosuccinimide; water; triethylamine; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1002/ardp.201600010

Reference yield:

: 1184914-03-1
2-amino-N-(2-methylphenyl)thiazole-5-carboxamide

: 1184919-23-0
N-(2-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate / tetrahydrofuran / 2.5 h / -15 °C

2: triethylamine / N,N-dimethyl-formamide / 4 h / 80 °C

With triethylamine; sodium t-butanolate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/ardp.201600010