2-Methyl-4-(pyridin-2-yl)pyrimidine

Base Information

• Chemical Name: 2-Methyl-4-(pyridin-2-yl)pyrimidine
• CAS No.: 25194-63-2
• Molecular Formula: C10H9N3
• Molecular Weight: 171.2
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00355800
• Nikkaji Number: J1.169.667H
• Wikidata: Q82134846
• Mol file: 25194-63-2.mol

Synonyms:2-methyl-4-(pyridin-2-yl)pyrimidine;25194-63-2;2-methyl-4-pyridin-2-ylpyrimidine;2-methyl-4-(2-pyridyl)pyrimidine;SCHEMBL14970145;DTXSID00355800;AKOS006273642;AC-907/25005027

Chemical Property of 2-Methyl-4-(pyridin-2-yl)pyrimidine

Chemical Property:

• PSA: 38.67000
• LogP: 1.84700
• Storage Temp.: 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 171.079647300
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-4-(pyridin-2-yl)pyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CC(=N1)C2=CC=CC=N2

Technology Process of 2-Methyl-4-(pyridin-2-yl)pyrimidine

There total 3 articles about 2-Methyl-4-(pyridin-2-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

acetamidine hydrochloride (124-42-5) + (2E)-3-(dimethylamino)-1-(2-pyridyl)prop-2-en-1-one (66521-54-8,75415-00-8,123367-25-9) → 2-methyl-4-(2-pyridyl)pyrimidine (25194-63-2)

Guidance literature:

With sodium; In ethanol; for 16h; Heating;

DOI:10.1039/a904617h

Reference yield: 46.0%

(2E)-3-(dimethylamino)-1-(2-pyridyl)prop-2-en-1-one (66521-54-8,75415-00-8,123367-25-9) + acetamidine (143-37-3) → 2-methyl-4-(2-pyridyl)pyrimidine (25194-63-2)

Guidance literature:

With sodium ethanolate; In ethanol; at 65 ℃; for 4h;

DOI:10.1039/c2dt12334g

Reference yield:

2-acetylpyridine (1122-62-9) → 2-methyl-4-(2-pyridyl)pyrimidine (25194-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / 110 °C

2: sodium ethanolate / ethanol / 4 h / 65 °C

With sodium ethanolate; In ethanol;

DOI:10.1039/c2dt12334g

upstream raw materials:

acetamidine hydrochloride

(2E)-3-(dimethylamino)-1-(2-pyridyl)prop-2-en-1-one

2-acetylpyridine

acetamidine