56517-53-4Relevant academic research and scientific papers
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility
Ohashi, Tomohiro,Oguro, Yuya,Tanaka, Toshio,Shiokawa, Zenyu,Tanaka, Yuta,Shibata, Sachio,Sato, Yoshihiko,Yamakawa, Hiroko,Hattori, Harumi,Yamamoto, Yukiko,Kondo, Shigeru,Miyamoto, Maki,Nishihara, Mitsuhiro,Ishimura, Yoshimasa,Tojo, Hideaki,Baba, Atsuo,Sasaki, Satoshi
, p. 5507 - 5517 (2012/10/30)
We recently reported the discovery of the novel pyrrolo[3,2-c]quinoline-4- one derivative 1 as a potent inhibitor of Hedgehog (Hh) pathway signaling. However, the PK evaluation of 1 at high dosage (100 mg/kg) revealed the C max value 3.63 μg/mL
4-hydroxy-2-quinolones. 95. Synthesis, structure, and antitubercular properties of hetarylamides of 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3- carboxylic acid
Ukrainets,Kolesnik,Sidorenko,Gorokhova,Turov
, p. 765 - 775 (2008/02/04)
The optimal conditions for obtaining hetarylamides of 4-hydroxy-2-oxo-1,2, 5,6,7,8-hexahydroquinoline-3-carboxylic acid are suggested on the basis of derivatographic investigations. The 1H NMR spectra of the synthesized compounds, their spatial
An Experimentally Convenient Preparation of Highly Substituted Pyridines
Rigby, James H.,Qabar, Maher
, p. 2699 - 2709 (2007/10/02)
A four step sequence is described for the conversion of α,β-unsaturated carboxylic acids into highly substituted pyridines.
Tetrahydrocarbostyril derivatives for the prophylaxis of asthma, hayfever and rhinitis
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, (2008/06/13)
Pharmaceutical compositions having anti-allergy activity in which the active anti-allergy agents are certain 3-nitro-α-pyridones and their pharmaceutically acceptable salts formulated in one or more pharmaceutically acceptable carriers.
