tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate

Base Information

• Chemical Name: tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate
• CAS No.: 1250996-70-3
• Molecular Formula: C12H19N3O3
• Molecular Weight: 253.3
• Mol file: 1250996-70-3.mol

Synonyms:tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate

Chemical Property of tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate

Chemical Property:

• Boiling Point: 462.9±40.0 °C(Predicted)
• PKA: 13.67±0.10(Predicted)
• PSA: 67.59000
• Density: 1.27±0.1 g/cm3(Predicted)
• LogP: 1.06400
• Storage Temp.: 2-8°C

Purity/Quality:

99.00% ^*data from raw suppliers

tert-Butyl2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate

There total 5 articles about tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

7-tert-butyl 2-methyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate → tert-butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate (1250996-70-3)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -40 - 20 ℃; for 3h;

Reference yield: 70.0%

7-(tert-butyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate (1053656-22-6) → tert-butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate (1250996-70-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2014.03.079

Reference yield:

ethyl imidazo[1,2-a]pyrazine-2-carboxylate (77112-52-8) → tert-butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate (1250996-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2014.03.079

upstream raw materials:

ethyl imidazo[1,2-a]pyrazine-2-carboxylate

7-(tert-butyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

di-tert-butyl dicarbonate

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