7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

Base Information

• Chemical Name: 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate
• CAS No.: 1053656-22-6
• Molecular Formula: C₁₄H₂₁N₃O₄
• Molecular Weight: 295.338
• Hs Code.: 2933990090
• Mol file: 1053656-22-6.mol

Synonyms:7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate;

Chemical Property of 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

Chemical Property:

• Boiling Point: 457.679 °C at 760 mmHg
• PKA: 4.06±0.20(Predicted)
• Flash Point: 230.596 °C
• PSA: 73.66000
• Density: 1.248 g/cm³
• LogP: 1.74840
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

7-tert-Butyl2-Ethyl5,6-Dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate

There total 6 articles about 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester hydrochloride (623564-18-1) + di-tert-butyl dicarbonate (24424-99-5) → 7-(tert-butyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate (1053656-22-6)

Guidance literature:

5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester hydrochloride; With triethylamine; In dichloromethane; at 0 ℃; for 10h;

di-tert-butyl dicarbonate; In dichloromethane; at 0 - 25 ℃;

Reference yield: 63.0%

di-tert-butyl dicarbonate (24424-99-5) + ethyl imidazo[1,2-a]pyrazine-2-carboxylate (77112-52-8) → 7-(tert-butyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate (1053656-22-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 24h;

DOI:10.1016/j.bmcl.2014.03.079

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate dihydrochloride (623564-18-1) → 7-(tert-butyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate (1053656-22-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.333333h;

upstream raw materials:

di-tert-butyl dicarbonate

tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazinecarboxylate-2 d'ethyle

ethyl imidazo[1,2-a]pyrazine-2-carboxylate

5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester hydrochloride

Downstream raw materials:

7-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)-N-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxamide

7-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)-N-(2-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxamide

C₂₅H₂₂ClFN₆O

7-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)-N-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxamide