2-Bromo-2,2-difluoro-1-phenylethanol

Base Information

Chemical Name:2-Bromo-2,2-difluoro-1-phenylethanol
CAS No.:74492-28-7
Molecular Formula:C₈H₇BrF₂O
Molecular Weight:237.044
Hs Code.:
DSSTox Substance ID:DTXSID90696613
Nikkaji Number:J3.313.731A

Synonyms:2-BROMO-2,2-DIFLUORO-1-PHENYLETHANOL;74492-28-7;2-Bromo-2,2-difluoro-1-phenylethan-1-ol;DTXSID90696613;MFCD18074357;1-Phenyl-2-bromo-2,2-difluoroethanol;CS-0365306

Suppliers and Price of 2-Bromo-2,2-difluoro-1-phenylethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 2-Bromo-2,2-difluoro-1-phenylethanol

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:235.96483
Heavy Atom Count:12
Complexity:146

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(C(F)(F)Br)O

Technology Process of 2-Bromo-2,2-difluoro-1-phenylethanol

There total 3 articles about 2-Bromo-2,2-difluoro-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610-04-4
α-bromo-α,α-difluoro-acetophenone

: 74492-28-7
2-bromo-2,2-difluoro-1-phenylethanol

Guidance literature:: With sodium hydroxide; sodium tetrahydroborate; In methanol; at -10 ℃;
DOI:10.1021/ja00782a031

Reference yield:

: 1616058-48-0
C₁₁H₁₅BrF₂OSi

: 74492-28-7
2-bromo-2,2-difluoro-1-phenylethanol

Guidance literature:: With potassium hydrogen bifluoride; trifluoroacetic acid; at 20 ℃; for 1h;
DOI:10.1021/ol501674n

Reference yield:

: 100-52-7
benzaldehyde

: 74492-28-7
2-bromo-2,2-difluoro-1-phenylethanol

Guidance literature:: Multi-step reaction with 2 steps

1: lithium bromide / 2 h / 170 °C / Inert atmosphere

2: trifluoroacetic acid; potassium hydrogen bifluoride / 1 h / 20 °C

With potassium hydrogen bifluoride; trifluoroacetic acid; lithium bromide;
DOI:10.1021/ol501674n