Difluorostyrene

Base Information

• Chemical Name: Difluorostyrene
• CAS No.: 405-42-5
• Molecular Formula: C8H6 F2
• Molecular Weight: 140.132
• Hs Code.: 2903999090
• Mol file: 405-42-5.mol

Synonyms:Styrene, b,b-difluoro- (6CI,7CI,8CI); b,b-Difluorostyrene

Chemical Property of Difluorostyrene

Chemical Property:

• Boiling Point: 65-66 °C(Press: 61-62 Torr)
• PSA: 0.00000
• Density: 1.124±0.06 g/cm3(Predicted)
• LogP: 2.92400
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Difluorostyrene

There total 60 articles about Difluorostyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzaldehyde (100-52-7) + potassium 2-bromo-2,2-difluoroacetate (87189-16-0) → 2',2'-difluorostyrene (405-42-5)

Guidance literature:

benzaldehyde; potassium 2-bromo-2,2-difluoroacetate; With triphenylphosphine; In N,N-dimethyl-formamide; at 90 ℃; for 1h; Sealed tube; Inert atmosphere;

With lithium chloride; methyl iodide; In diethyl ether; water;

DOI:10.1021/acs.joc.0c02440

Reference yield: 70.0%

iodobenzene (591-50-4) + 2,2-difluorovinylzinc chloride (101032-99-9) → 2',2'-difluorostyrene (405-42-5)

Guidance literature:

With sulfuric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1016/0022-328X(87)80001-3

Reference yield: 67.0%

2,2-difluoro-1-phenylethenyl diphenyl phosphate (89264-10-8) → 2',2'-difluorostyrene (405-42-5)

Guidance literature:

With copper(l) iodide; n-butyllithium; water; In tetrahydrofuran; at -60 ℃; for 1h;

DOI:10.1016/S0040-4039(00)94166-2

upstream raw materials:

1,2-dichloro-1-phenyl-2,2-difluoroethane

1,1,2,2-tetrafluoro-3-phenylcyclobutane

1,1,1-trifluoro-2,2-dichloro-2-phenylethane

dibromodifluoromethane

Downstream raw materials:

1,2-dichloro-1-phenyl-2,2-difluoroethane

(1,2-dibromo-2,2-difluoro-ethyl)-benzene

benzeneacetic acid methyl ester

1-Trimethylhydrazino-2-phenylacetylene

Refernces

• 1、 Hayashi,S. et al.. "-". . p. 983 - 986. Retrieved 1979.
• 2、 Carreras, Virginie,Ollevier, Thierry. "Fluoride-Triggered Synthesis of 1-Aryl-2,2-difluoroalkenes via Desilylative Defluorination of (1-Aryl)-2,2,2-trifluoroethyl-silanes". . p. 13160 - 13168. Retrieved 2021/09/18.
• 3、 Liu, Jiawang,Yang, Ji,Ferretti, Francesco,Jackstell, Ralf,Beller, Matthias. "Pd-Catalyzed Selective Carbonylation of gem-Difluoroalkenes: A Practical Synthesis of Difluoromethylated Esters". supporting information. p. 4690 - 4694. Retrieved 2019/03/13.