Formiminoglutamic acid

Base Information

• Chemical Name: Formiminoglutamic acid
• CAS No.: 816-90-0
• Molecular Formula: C6H10 N2 O4
• Molecular Weight: 174.156
• European Community (EC) Number: 212-439-7
• UNII: YV703N7VOG
• DSSTox Substance ID: DTXSID40862422
• Nikkaji Number: J193.205E
• Wikipedia: Formiminoglutamic_acid
• Wikidata: Q2823262
• Metabolomics Workbench ID: 37465
• Mol file: 816-90-0.mol

Synonyms:Acid, Formiminoglutamic;FIGLU;Formiminoglutamic Acid

Chemical Property of Formiminoglutamic acid

Chemical Property:

• Vapor Pressure: 3.93E-07mmHg at 25°C
• Boiling Point: 389°C at 760 mmHg
• PKA: 3.33±0.10(Predicted)
• Flash Point: 189°C
• PSA: 110.48000
• Density: 1.45g/cm³
• LogP: -0.00830
• Storage Temp.: −20°C
• Solubility.: Aqueous Acid (Slightly, Sonicated), Water (Slightly)
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 174.06405680
• Heavy Atom Count: 12
• Complexity: 202

Purity/Quality:

99% ^*data from raw suppliers

L-FormiminoglutamicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(=O)O)C(C(=O)O)N=CN
• Isomeric SMILES: C(CC(=O)O)[C@@H](C(=O)O)N=CN

Technology Process of Formiminoglutamic acid

There total 3 articles about Formiminoglutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-formimidoyl-L-glutamic acid-5-benzyl ester → N-formimidoyl-L-glutamic acid (816-90-0)

Guidance literature:

With methanol; palladium; Hydrogenation;

DOI:10.1021/ja01652a101

Reference yield:

L-glutamic acid γ-benzyl ester (1676-73-9,25014-27-1) → N-formimidoyl-L-glutamic acid (816-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: formamide; Ag₂CO₃

2: palladium; methanol / Hydrogenation

With methanol; palladium; formamide; silver carbonate;

DOI:10.1021/ja01652a101

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + formamidine hydrochloride (6313-33-3) → N-formimidoyl-L-glutamic acid (816-90-0)

Guidance literature:

With formamide; silver carbonate;

upstream raw materials:

L-glutamic acid

formamidine hydrochloride

L-glutamic acid γ-benzyl ester

Downstream raw materials:

N-(10-formyl-7,8-dihydro-pteroyl)-L-glutamic acid

N-((S)-5-formimidoyl-5,6,7,8-tetrahydro-pteroyl)-L-glutamic acid