6-Chloroimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 6-Chloroimidazo[1,2-a]pyridine
• CAS No.: 6188-25-6
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.583
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00377406
• Nikkaji Number: J2.521.554K
• Wikidata: Q72452085
• Mol file: 6188-25-6.mol

Synonyms:6-chloroimidazo[1,2-a]pyridine;6188-25-6;6-chloro-Imidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine, 6-chloro-;MFCD05663807;6-Chloroimidazo(1,2-a)pyridine;6-chloroH-imidazo[1,2-a]pyridine;SCHEMBL162566;DTXSID00377406;XQEGYCZJSVFGEE-UHFFFAOYSA-N;AKOS005071101;AB21919;CS-W022490;6-Chloroimidazo[1 pound not2-a]pyridine;AC-27294;SY019456;6-Chloroimidazo[1,2-a]pyridine, AldrichCPR;AM20061377;C3370;FT-0648654;EN300-120792;7X-0892;A833463;J-518612

Chemical Property of 6-Chloroimidazo[1,2-a]pyridine

Chemical Property:

• Melting Point: 85-87 °C
• Refractive Index: 1.653
• Boiling Point: 132°C/1.5mmHg(lit.)
• PKA: 5.18±0.50(Predicted)
• PSA: 17.30000
• Density: 1.35 g/cm³
• LogP: 1.98770
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 152.0141259
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

97% ^*data from raw suppliers

6-Chloroimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=CN2C=C1Cl
• Uses: 6-Chlorimidazo[1,2-A]pyridine is a pyridine derivative and can be used as a pharmaceutical intermediate.

Technology Process of 6-Chloroimidazo[1,2-a]pyridine

There total 3 articles about 6-Chloroimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

→ 6-Chloro-imidazo[1,2-a]pyridine (6188-25-6)

Guidance literature:

Reference yield:

2-chloroethanal (107-20-0) + 5-chloro-2-pyridylamine (1072-98-6) → 6-Chloro-imidazo[1,2-a]pyridine (6188-25-6)

Guidance literature:

In ethanol; water; at 80 ℃; for 16h;

Reference yield:

2-chloroethanal (107-20-0) + 6-Chloro-pyridin-3-ylamine (5350-93-6) → 6-Chloro-imidazo[1,2-a]pyridine (6188-25-6)

Guidance literature:

In ethanol; water; for 3h; Heating / reflux;

upstream raw materials:

2-chloroethanal

6-Chloro-pyridin-3-ylamine

5-chloro-2-pyridylamine

Downstream raw materials:

8-chloro-3-phenylimidazo[1,2-α]pyridine

6-chloro-3-m-tolyl-imidazo[1,2-a]pyridine

6-chloro-3-(triphenylvinyl)imidazo[1,2-a]pyridine

3-bromo-6-chloroimidazo[1,2-a]pyridine