1,2,3,4-TETRAHYDRO-1,3-DIMETHYL-BETA,2,4-TRIOXO-6-(PHENYLAMINO)-5-PYRIMIDINEPROPANENITRILE

Base Information

• Chemical Name: 1,2,3,4-TETRAHYDRO-1,3-DIMETHYL-BETA,2,4-TRIOXO-6-(PHENYLAMINO)-5-PYRIMIDINEPROPANENITRILE
• CAS No.: 132373-29-6
• Molecular Formula: C15H14N4O3
• Molecular Weight: 298.3
• Mol file: 132373-29-6.mol

Synonyms:1,2,3,4-TETRAHYDRO-1,3-DIMETHYL-BETA,2,4-TRIOXO-6-(PHENYLAMINO)-5-PYRIMIDINEPROPANENITRILE

Chemical Property of 1,2,3,4-TETRAHYDRO-1,3-DIMETHYL-BETA,2,4-TRIOXO-6-(PHENYLAMINO)-5-PYRIMIDINEPROPANENITRILE

Chemical Property:

• PSA: 96.89000
• LogP: 0.99698

Purity/Quality:

1,2,3,4-TETRAHYDRO-1,3-DIMETHYL-BETA-2,4-TRIOXO-6-(PHENYLAMINO)-5-PYRIMIDINEPROPANENITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-TETRAHYDRO-1,3-DIMETHYL-BETA,2,4-TRIOXO-6-(PHENYLAMINO)-5-PYRIMIDINEPROPANENITRILE

There total 1 articles about 1,2,3,4-TETRAHYDRO-1,3-DIMETHYL-BETA,2,4-TRIOXO-6-(PHENYLAMINO)-5-PYRIMIDINEPROPANENITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-anilino-1,3-dimethyluracil (7278-51-5) + cyanoacetic acid (372-09-8) → 5-cyanoacetyl-6-phenylaminouracil (132373-29-6)

Guidance literature:

With acetic anhydride; at 80 ℃;

DOI:10.1007/BF00509714

Reference yield: 97.0%

5-cyanoacetyl-6-phenylaminouracil (132373-29-6) + N,N-dimethylacetamide diethyl acetal (19429-85-7) → 1,3,7-Trimethyl-2,4,5-trioxo-8-phenyl-1,2,3,4,5,8-hexahydro-pyrido[2,3-d]pyrimidine-6-carbonitrile

Guidance literature:

at 20 ℃; for 0.5h;

DOI:10.1007/BF02218996

Reference yield: 92.0%

5-cyanoacetyl-6-phenylaminouracil (132373-29-6) → 1,3-dimethyl-5-hydroxy-8-phenyl-1,2,3,4,7,8-hexahydropyrido<2,3-d>pyrimidine-2,4,7-trione (137278-09-2)

Guidance literature:

With hydrogen bromide; at 80 - 90 ℃; for 0.5h;

DOI:10.1007/BF00474003

upstream raw materials:

6-anilino-1,3-dimethyluracil

cyanoacetic acid

Downstream raw materials:

1,3-dimethyl-5-hydroxy-8-phenyl-1,2,3,4,7,8-hexahydropyrido<2,3-d>pyrimidine-2,4,7-trione

1,3-Dimethyl-2,4,5-trioxo-8-phenyl-1,2,3,4,5,8-hexahydro-pyrido[2,3-d]pyrimidine-6-carbonitrile