(S)-tert-butyl 6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate
CAS No.:1262397-26-1
Molecular Formula:C12H22N2O2
Molecular Weight:226.319
Hs Code.:
Mol file:1262397-26-1.mol

Synonyms:(S)-tert-butyl 6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate

Suppliers and Price of (S)-tert-butyl 6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-tert-Butyl6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate 95+%
1g
$ 932.00

Chemenu
(S)-tert-Butyl6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate 95%
1g
$ 879.00

Alichem
(S)-Tert-Butyl6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate
1g
$ 1079.10

Activate Scientific
(S)-5-(Boc)-6-(aminomethyl)-5-azaspiro[2.4]heptane 97% ee
1 g
$ 1040.00

Activate Scientific
(S)-5-(Boc)-6-(aminomethyl)-5-azaspiro[2.4]heptane 97% ee
250 mg
$ 486.00

Activate Scientific
(S)-5-(Boc)-6-(aminomethyl)-5-azaspiro[2.4]heptane 97% ee
100 mg
$ 280.00

Total 5 raw suppliers

Chemical Property of (S)-tert-butyl 6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate

Chemical Property:

PSA：55.56000
LogP:2.37290

Purity/Quality:

99%, ^*data from raw suppliers

(S)-tert-Butyl6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate

There total 8 articles about (S)-tert-butyl 6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1262397-24-9
(S)-tert-butyl 6-((1,3-dioxoisoindolin-2-yl)methyl)-5-azaspiro[2.4]heptane-5-carboxylate

: 1262397-26-1
(S)-tert-butyl 6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate

Guidance literature:: With hydrazine hydrate; In ethanol; at 20 ℃;

Reference yield:

: 1262397-06-7
tert-butyl 4-methylene-2(S)-((4-nitrobenzoyloxy)methyl)pyrrolidine-1-carboxylate

: 1262397-26-1
(S)-tert-butyl 6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate / tetrahydrofuran / 2 h / 20 °C

1.2: -60 - 20 °C

2.1: sodium hydroxide / water; methanol / 0 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 0 - 20 °C / Inert atmosphere; Cooling

4.1: hydrazine hydrate / ethanol / 20 °C

With hydrazine hydrate; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; toluene;

Reference yield:

: 1262397-12-5
(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

: 1262397-26-1
(S)-tert-butyl 6-(aminomethyl)-5-azaspiro[2.4]heptane-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 0 - 20 °C / Inert atmosphere; Cooling

2: hydrazine hydrate / ethanol / 20 °C

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; toluene;