(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester
CAS No.:1262397-12-5
Molecular Formula:C₁₂H₂₁NO₃
Molecular Weight:227.304
Hs Code.:

Synonyms:(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

Suppliers and Price of (S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of (S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

There total 1 articles about (S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 1262397-12-5
(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / toluene / Reflux; Dean-Stark

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -50 - -40 °C

2.2: 0.5 h / -55 - -45 °C

3.1: potassium hydrogencarbonate / methanol; water / 10 - 50 °C

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 10 - 60 °C

4.2: 10 - 60 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 50 - 60 °C

6.1: palladium 10% on activated carbon; ammonium formate / methanol; water / 10 - 50 °C / Inert atmosphere

7.1: dichloromethane / 20 - 45 °C

7.2: 20 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; potassium tert-butylate; ammonium formate; potassium hydrogencarbonate; toluene-4-sulfonic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

Reference yield: 70.0%

: 1262397-12-5
(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

: 1129634-44-1,1454843-77-6,1454843-78-7
(6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid

Guidance literature:: With Jones reagent; In acetone; at 0 - 37 ℃; for 2h;

Reference yield:

: 1262397-12-5
(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

: 1445596-11-1
(S)-tert-butyl 6-((((benzyloxy)carbonyl)amino)methyl)-5-azaspiro[2.4]heptane-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C / Inert atmosphere; Cooling with ice

2: hydrazine hydrate / ethanol / 20 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; toluene; acetonitrile;