(S)-benzyl ((5-(6-methyl-3-(pyrimidin-2-yl)picolinoyl)-5-azaspiro[2.4]heptan-6-yl)methyl)carbamate

Base Information

Chemical Name:(S)-benzyl ((5-(6-methyl-3-(pyrimidin-2-yl)picolinoyl)-5-azaspiro[2.4]heptan-6-yl)methyl)carbamate
CAS No.:1445596-13-3
Molecular Formula:C₂₆H₂₇N₅O₃
Molecular Weight:457.532
Hs Code.:

Synonyms:(S)-benzyl ((5-(6-methyl-3-(pyrimidin-2-yl)picolinoyl)-5-azaspiro[2.4]heptan-6-yl)methyl)carbamate

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Chemical Property of (S)-benzyl ((5-(6-methyl-3-(pyrimidin-2-yl)picolinoyl)-5-azaspiro[2.4]heptan-6-yl)methyl)carbamate

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Technology Process of (S)-benzyl ((5-(6-methyl-3-(pyrimidin-2-yl)picolinoyl)-5-azaspiro[2.4]heptan-6-yl)methyl)carbamate

There total 9 articles about (S)-benzyl ((5-(6-methyl-3-(pyrimidin-2-yl)picolinoyl)-5-azaspiro[2.4]heptan-6-yl)methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228188-18-8
6-methyl-3-(pyrimidin-2-yl)pyridine-2-carboxylic acid

: 1445596-12-2
(S)-benzyl (5-azaspiro[2.4]heptan-6-ylmethyl)carbamate

: 1445596-13-3
(S)-benzyl ((5-(6-methyl-3-(pyrimidin-2-yl)picolinoyl)-5-azaspiro[2.4]heptan-6-yl)methyl)carbamate

Guidance literature:: 6-methyl-3-(pyrimidin-2-yl)pyridine-2-carboxylic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In 1,4-dioxane; at 40 ℃; for 1h;

(S)-benzyl (5-azaspiro[2.4]heptan-6-ylmethyl)carbamate; In 1,4-dioxane; at 80 ℃; for 1.5h;

Reference yield:

: 1262397-12-5
(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

: 1445596-13-3
(S)-benzyl ((5-(6-methyl-3-(pyrimidin-2-yl)picolinoyl)-5-azaspiro[2.4]heptan-6-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C / Inert atmosphere; Cooling with ice

2.1: hydrazine hydrate / ethanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 1 h / 40 °C

5.2: 1.5 h / 80 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1431322-86-9
(S)-1-(5-azaspiro[2.4]hept-6-yl)methanol

: 1445596-13-3
(S)-benzyl ((5-(6-methyl-3-(pyrimidin-2-yl)picolinoyl)-5-azaspiro[2.4]heptan-6-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 2 h / 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C / Inert atmosphere; Cooling with ice

3.1: hydrazine hydrate / ethanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

6.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 1 h / 40 °C

6.2: 1.5 h / 80 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; acetonitrile;