1-(2-methoxyphenyl)cyclobutane-1-carboxylic acid

Base Information

• Chemical Name: 1-(2-methoxyphenyl)cyclobutane-1-carboxylic acid
• CAS No.: 74205-38-2
• Molecular Formula: C12H14O3
• Molecular Weight: 206.24
• Hs Code.: 2918990090
• Mol file: 74205-38-2.mol

Synonyms:1-(2-methoxyphenyl)cyclobutane-1-carboxylic acid;1-(2-METHOXYPHENYL)CYCLOBUTANECARBOXYLIC ACID;2-(1-Carboxycyclobut-1-yl)anisole, 1-Carboxy-1-(2-methoxyphenyl)cyclobutane

Chemical Property of 1-(2-methoxyphenyl)cyclobutane-1-carboxylic acid

Chemical Property:

• PSA: 46.53000
• LogP: 2.20150

Purity/Quality:

97% ^*data from raw suppliers

1-(2-Methoxyphenyl)cyclobutane-1-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-methoxyphenyl)cyclobutane-1-carboxylic acid

There total 3 articles about 1-(2-methoxyphenyl)cyclobutane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.3%

1-(2-methoxyphenyl)cyclobutane-1-carbonitrile (74205-10-0) → 1-(2-methoxyphenyl)cyclobutanecarboxylic acid (74205-38-2)

Guidance literature:

With potassium hydroxide; In diethylene glycol; for 8h; Heating;

DOI:10.1007/BF00765910

Reference yield:

2-methoxy-benzeneacetonitrile (7035-03-2) → 1-(2-methoxyphenyl)cyclobutanecarboxylic acid (74205-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium amide / 1.) toluene, heating, 1 h, 2.) overnight; heating, 6 h

2: 77.3 percent / KOH / bis-(2-hydroxy-ethyl) ether / 8 h / Heating

With potassium hydroxide; sodium amide; In diethylene glycol;

DOI:10.1007/BF00765910

Reference yield:

→ 1-(2-methoxyphenyl)cyclobutanecarboxylic acid (74205-38-2)

Guidance literature:

upstream raw materials:

1-(2-methoxyphenyl)cyclobutane-1-carbonitrile

2-methoxy-benzeneacetonitrile

Downstream raw materials:

(2S,5R,6R)-6-{[1-(2-Methoxy-phenyl)-cyclobutanecarbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

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