Thiazole, 2-phenyl-4-[4-(trifluoromethyl)phenyl]-

Base Information

• Chemical Name: Thiazole, 2-phenyl-4-[4-(trifluoromethyl)phenyl]-
• CAS No.: 533867-27-5
• Molecular Formula: C16H10F3NS
• Molecular Weight: 305.3175096
• Mol file: 533867-27-5.mol

Synonyms:Thiazole, 2-phenyl-4-[4-(trifluoromethyl)phenyl]-;2-phenyl-4-[4-(trifluoroMethyl)phenyl]-1,3-thiazole;2-Phenyl-4-(4-(trifluoromethyl)phenyl)thiazole

Chemical Property of Thiazole, 2-phenyl-4-[4-(trifluoromethyl)phenyl]-

Chemical Property:

• PSA: 41.13000
• LogP: 5.49590

Purity/Quality:

98% ^*data from raw suppliers

2-Phenyl-4-(4-(trifluoromethyl)phenyl)thiazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiazole, 2-phenyl-4-[4-(trifluoromethyl)phenyl]-

There total 5 articles about Thiazole, 2-phenyl-4-[4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

→ 4-(4-trifluoromethyl-phenyl)-2-phenyl-thiazole (533867-27-5)

Guidance literature:

In ethanol; for 4h; Reflux;

Reference yield: 93.0%

2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone (383-53-9) + benzenecarbothioamide (2227-79-4) → 4-(4-trifluoromethyl-phenyl)-2-phenyl-thiazole (533867-27-5)

Guidance literature:

In isopropyl alcohol; at 27 ℃; for 2h;

DOI:10.1016/S0040-4020(03)00018-8

Reference yield:

1-(4-trifluoromethylphenyl)ethanone (709-63-7) → 4-(4-trifluoromethyl-phenyl)-2-phenyl-thiazole (533867-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. HBr; bromine / acetic acid / 1.5 h / 15 °C

2: 93 percent / propan-2-ol / 2 h / 27 °C

With hydrogen bromide; bromine; In acetic acid; isopropyl alcohol;

DOI:10.1016/S0040-4020(03)00018-8

upstream raw materials:

2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

benzenecarbothioamide

1-(4-trifluoromethylphenyl)ethanone

thiobenzoic acid potassium salt

Downstream raw materials:

4-[4-(4-trifluoromethyl-phenyl)-thiazol-2-yl]-bezenesulfonyl chloride

(R)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-2-(4-{4-[4-trifluoromethyl-phenyl-thiazol-2-yl]-benzenesulfonylamino}-phenyl)-acetamide

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