3-Fluoro-4-nitrophenylboronic acid,pinacol ester

Base Information

• Chemical Name: 3-Fluoro-4-nitrophenylboronic acid,pinacol ester
• CAS No.: 939968-60-2
• Molecular Formula: C12H15BFNO4
• Molecular Weight: 267.065
• Hs Code.: 2931900090
• Mol file: 939968-60-2.mol

Synonyms:3-Fluoro-4-nitrophenylboronic acid,pinacol ester;2-(3-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;4-Fluoro-3-nitrobenzeneboronic acid pinacol ester, 96%;3-Fluoro-4-nitrobenzeneboronic acid pinacol ester, 96%

Chemical Property of 3-Fluoro-4-nitrophenylboronic acid,pinacol ester

Chemical Property:

• PSA: 64.28000
• LogP: 2.55630

Purity/Quality:

98.5% ^*data from raw suppliers

3-Fluoro-4-nitrophenylboronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Fluoro-4-nitrophenylboronic acid, pinacol ester

Technology Process of 3-Fluoro-4-nitrophenylboronic acid,pinacol ester

There total 2 articles about 3-Fluoro-4-nitrophenylboronic acid,pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

4-bromo-2-fluoronitrobenzene (321-23-3) + bis(pinacol)diborane (73183-34-3) → 2-(3-fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (939968-60-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 90 ℃; for 12h; Inert atmosphere;

Reference yield: 61.0%

3-fluoro-4-nitroaniline (2369-13-3) + bis(pinacol)diborane (73183-34-3) → 2-(3-fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (939968-60-2)

Guidance literature:

With tert.-butylnitrite; 2-(4-biphenylyl)-5-phenyloxazole; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1021/jo402618r

Reference yield: 92.0%

2-Chloroquinoline (612-62-4) + 2-(3-fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (939968-60-2) → C15H9FN2O2 (1374110-19-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 16h; Inert atmosphere;

upstream raw materials:

4-bromo-2-fluoronitrobenzene

bis(pinacol)diborane

3-fluoro-4-nitroaniline

Downstream raw materials:

5-(3-fluoro-4-nitrophenyl)-6-(4-fluorophenyl)-imidazo[2,1-b]oxazole

C₁₅H₉FN₂O₂

C₁₅H₁₀N₂O₃

C₂₄H₂₉FN₂O₄Si

Refernces

• 1、 -. "Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof". Paragraph 0721; 0723; 0724. . Retrieved 2020/08/28.
• 2、 -. "Heterocyclic compound". Paragraph 0270. . Retrieved 2017/09/28.