Ziprasidone IMpurity (6-Chloro-5-(2-Chloro-1-Hydroxy-Ethyl)-1,3-Dihydro-Indol-2-One)

Base Information

Chemical Name:Ziprasidone IMpurity (6-Chloro-5-(2-Chloro-1-Hydroxy-Ethyl)-1,3-Dihydro-Indol-2-One)
CAS No.:884305-06-0
Molecular Formula:C10H9Cl2NO2
Molecular Weight:246.093
Hs Code.:
Mol file:884305-06-0.mol

Synonyms:Ziprasidone IMpurity (6-Chloro-5-(2-Chloro-1-Hydroxy-Ethyl)-1,3-Dihydro-Indol-2-One)

Suppliers and Price of Ziprasidone IMpurity (6-Chloro-5-(2-Chloro-1-Hydroxy-Ethyl)-1,3-Dihydro-Indol-2-One)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Chloro-5-(2-chloro-1-hydroxyethyl)-1,3-dihydro-2H-indol-2-one
25mg
$ 1250.00

Total 6 raw suppliers

Chemical Property of Ziprasidone IMpurity (6-Chloro-5-(2-Chloro-1-Hydroxy-Ethyl)-1,3-Dihydro-Indol-2-One)

Chemical Property:

PSA：49.33000
LogP:2.24480
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:DMF (Slightly, Sonicated), DMSO (Slightly)

Purity/Quality:

95% ^*data from raw suppliers

6-Chloro-5-(2-chloro-1-hydroxyethyl)-1,3-dihydro-2H-indol-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 6-Chloro-5-(2-chloro-1-hydroxyethyl)-1,3-dihydro-2H-indol-2-one is an impurity inthe synthesis of Hydroxy Ziprasidone which is an impurity of Ziprasidone (Z485000); a combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Used as an antipsychotic.

Technology Process of Ziprasidone IMpurity (6-Chloro-5-(2-Chloro-1-Hydroxy-Ethyl)-1,3-Dihydro-Indol-2-One)

There total 4 articles about Ziprasidone IMpurity (6-Chloro-5-(2-Chloro-1-Hydroxy-Ethyl)-1,3-Dihydro-Indol-2-One) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118307-04-3
6-chloro-5-(2-chloroacetyl) indolin-2-one

: 884305-06-0
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Guidance literature:: With triethylsilane; trifluoroacetic acid; for 7h;

Reference yield:

: 118307-04-3
6-chloro-5-(2-chloroacetyl) indolin-2-one

: 884305-06-0
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

: 6-chloro-5-ethylindolin-2-one

: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Guidance literature:: With triethylsilane; aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere; Reflux;
DOI:10.1021/op800105j

Reference yield:

: 56341-37-8
6-chloro-2-oxindole

: 884305-06-0
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

: 118289-55-7
6-chloro-5-(2-chloroethyl)-2-oxindole

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 20 h / Reflux; Inert atmosphere

2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / dichloromethane / 0 °C / Inert atmosphere

With aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane; In dichloromethane; 1: |Friedel-Crafts Acylation;
DOI:10.1021/op800105j