118307-04-3

Basic information

• Product Name: 5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one
• Synonyms: 5-CHLOROACETYL-6-CHLORO-1,3-DIHYDRO-2H-INDOLE-2-ONE;5-CHLOROACETYL-6-CHLOROOXINDOLE;6-CHLORO-5-(CHLOROACETYL)-1,3-DIHYDRO-2H-INDOL-2-ONE;5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indol-2-one;5-CHLOROACETYL-6-CHLOROL-1,3-DIHYDRO-2H-INDOLE-2-ONE;5-cloroacetyl-6-chlorooxindole;5-Chloroacetyl-6-chloro-1,3-dihydroindol-2H-indone-2-one;5-Chloroacetyl-6-chlorol-1,3-d
• CAS NO: 118307-04-3
• Molecular Formula: C₁₀H₇Cl₂NO₂
• Molecular Weight: 244.07
• EINECS: 1533716-785-6
• Product Categories: blocks;IndolesOxindoles;Indoles and derivatives;Indoline & Oxindole;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 118307-04-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 202-206°C
• Boiling Point: 430.1 °C at 760 mmHg
• Flash Point: 213.9 °C
• Appearance: Light brown solid
• Density: 1.471 g/cm³
• Vapor Pressure: 6.54E-08mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: 12.55±0.20(Predicted)
• CAS DataBase Reference: 5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one(118307-04-3)
• EPA Substance Registry System: 5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one(118307-04-3)

Safety Data

• Hazard Codes: Xi
• Statements: 34
• Safety Statements: 26-36/37/39-24/25
• RIDADR: 3261
• Hazardous Substances Data: 118307-04-3(Hazardous Substances Data)

Usage

Chemical Properties

Light Brown Solid

Uses

5-Chloroacetyl-6-chloro-1,3-dihydroindol-2H-indone-2-one (cas# 118307-04-3) is a compound useful in organic synthesis.

InChI:InChI=1/C10H7Cl2NO2/c11-4-9(14)6-1-5-2-10(15)13-8(5)3-7(6)12/h1,3H,2,4H2,(H,13,15)

Upstream product

• 89-61-2 2,5-dichloronitrobenzene 
• 147124-32-1 dimethyl (4-chloro-2-nitrophenyl)malonate 
• 79-04-9 chloroacetyl chloride 
• 56341-37-8 6-chloro-2-oxindole 

Downstream Products

• 884305-07-1 5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-1-oxoethyl)-6-chloro-1,3-dihydro-2H-indole-2-one 
• 884305-06-0 6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one 
• 118289-55-7 6-chloro-5-(2-chloroethyl)-2-oxindole 
• 1156390-49-6 6-chloro-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid 
• 884305-08-2 5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-1-hydroxyethyl)-6-chloro-1,3-dihydro-2H-indole-2-one 
• 122883-93-6 ziprazidone 

Relevant articles and documents

Impurity in ziprasidone hydrochloride and preparation method of impurity

The invention provides an impurity in ziprasidone hydrochloride. The impurity has a structure as shown in formula 1. According to the present invention, the impurity with the specific structure is obtained based on incomplete reaction during the ziprasidone hydrochloride preparation process, and the impurity is introduced and transferred to a final product, and the corresponding impurity preparation steps are provided so as to provide the corresponding technical support for the ziprasidone hydrochloride preparation. The synthesis method provided by the invention is simple in process, high in controllability and mild in condition, can be used for quality standard establishment and quality control links such as ziprasidone hydrochloride process research and development, production and the like, and provides technical support for ziprasidone hydrochloride medication safety. The method can be used for quality research such as qualitative and quantitative analysis of impurities in ziprasidone hydrochloride synthesis, so that improvement of the quality of ziprasidone hydrochloride is facilitated, and great guiding significance is provided for reducing the medication risk of ziprasidone hydrochloride.

A SHORT PROCESS FOR THE PREPARATION OF ZIPRASIDONE AND INTERMEDIATES THEREOF

A process for the preparation of oxindole derivative (Ziprasidone hydrochloride) of formula (I) comprising reacting compound of formula (II) with metal or metal compound mineral acid to give compound of formula (III) in a single step which is converted into compound of formula IV which is a key intermediate for the preparation of compound of compound of formula (I).

Ziprasidone process

A process for preparing ziprasidone having low levels of keto ziprasidone and hydroxy ziprasidone impurities.