15,16-Deshydroxy 3-O-Benzyl Estetrol 17-Acetate

Base Information

• Chemical Name: 15,16-Deshydroxy 3-O-Benzyl Estetrol 17-Acetate
• CAS No.: 690996-25-9
• Molecular Formula: C₂₇H₃₀O₃
• Molecular Weight: 402.533
• Mol file: 690996-25-9.mol

Synonyms:15,16-Deshydroxy 3-O-Benzyl Estetrol 17-Acetate;(17β)-3-(PhenylMethoxy)-estra-1,3,5(10),15-tetraen-17-ol Acetate

Chemical Property of 15,16-Deshydroxy 3-O-Benzyl Estetrol 17-Acetate

Chemical Property:

• PSA: 35.53000
• LogP: 5.82940
• Solubility.: Chloroform

Purity/Quality:

99% ^*data from raw suppliers

15,16-Deshydroxy3-O-BenzylEstetrol17-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 15,16-Deshydroxy 3-O-Benzyl Estetrol 17-Acetate

There total 12 articles about 15,16-Deshydroxy 3-O-Benzyl Estetrol 17-Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-benzyloxy-estra-1,3,5(10),15-tetraen-17β-ol (690996-26-0) + acetic anhydride (108-24-7) → 17-acetyloxy-3-benzyloxy-estra-1,3,5(10),15-tetraene (690996-25-9)

Guidance literature:

With pyridine; dmap; at 20 ℃; for 2h;

Reference yield: 73.0%

3-benzyloxy-estra-1,3,5(10),15-tetraene-17-ol (690996-26-0) + acetic anhydride (108-24-7) → 17β-acetyloxy-3-benzyloxy-estra-1,3,5(10),15-tetraene (690996-25-9)

Guidance literature:

With pyridine; dmap; at 20 ℃; for 2h;

Reference yield:

Estrone (53-16-7) → 17β-acetyloxy-3-benzyloxy-estra-1,3,5(10),15-tetraene (690996-25-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / dichloromethane; methanol / 16 h / Reflux

2.1: triethylamine / dichloromethane / 1 h / 20 °C

3.1: oxygen / palladium diacetate / dichloromethane; dimethyl sulfoxide / 35 °C

4.1: cerium(III) chloride heptahydrate / tetrahydrofuran; methanol / 1 h / 20 °C

4.2: 2 h / 0 - 8 °C

5.1: pyridine / dmap / 2 h / 20 °C

With pyridine; cerium(III) chloride heptahydrate; oxygen; potassium carbonate; triethylamine; dmap; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

3-benzyloxy-estra-1,3,5⁽¹⁰⁾,15-tetraene-17-ol

acetic anhydride

benzyl bromide

Estrone

Downstream raw materials:

17-acetyl estetrol

17-acetyl estetrol

17-acetyl-3-benzyl estetrol