3-(2-Chloroacetyl)-1,3-oxazolidin-2-one

Base Information

• Chemical Name: 3-(2-Chloroacetyl)-1,3-oxazolidin-2-one
• CAS No.: 460313-68-2
• Molecular Formula: C5H6ClNO3
• Molecular Weight: 163.55904
• European Community (EC) Number: 888-503-9
• Mol file: 460313-68-2.mol

Synonyms:460313-68-2;3-(2-chloroacetyl)-1,3-oxazolidin-2-one;3-(chloroacetyl)-1,3-oxazolidin-2-one;3-(2-chloroacetyl)oxazolidin-2-one;chloroacetyl oxazolidinone;SCHEMBL1973483;AKOS009020486;2-Oxazolidinone,3-(chloroacetyl)-(9ci);EN300-14206;Z99599048

Chemical Property of 3-(2-Chloroacetyl)-1,3-oxazolidin-2-one

Chemical Property:

• PSA: 46.61000
• LogP: 0.14190
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 163.0036207
• Heavy Atom Count: 10
• Complexity: 170

Purity/Quality:

3-(2-chloroacetyl)-1,3-oxazolidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(=O)N1C(=O)CCl

Technology Process of 3-(2-Chloroacetyl)-1,3-oxazolidin-2-one

There total 1 articles about 3-(2-Chloroacetyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

dimethylenecyclourethane (497-25-6) + chloroacetyl chloride (79-04-9) → 3-(2-chloroacetyl)oxazolidin-2-one (460313-68-2)

Guidance literature:

In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1002/anie.200462125

Reference yield:

carbonic acid tert-butyl ester 3-hydroxy-4-(3-phenyl-propyl)-phenyl ester (919110-97-7) + 3-(2-chloroacetyl)oxazolidin-2-one (460313-68-2) → carbonic acid tert-butyl ester 3-[2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethoxy]-4-(3-phenyl-propyl)-phenyl ester

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetone;

DOI:10.1021/ja062987w

Reference yield:

3-(2-chloroacetyl)oxazolidin-2-one (460313-68-2) + carbonic acid 2-bromo-3-hydroxy-4-(3-phenyl-propyl)-phenyl ester tert-butyl ester (680997-62-0) → carbonic acid 2-bromo-3-[2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethoxy]-4-(3-phenyl-propyl)-phenyl ester tert-butyl ester

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetone;

DOI:10.1021/ja062987w

upstream raw materials:

dimethylenecyclourethane

chloroacetyl chloride

Downstream raw materials:

1,3-oxazolidin-2-on-3-ylcarbonylmethylenetriphenylphosphorane

(3'R,4''S)-3-[3'-benzyloxyamino-3'-(2'',2''-dimethyl-1'',3''-dioxolan-4''-yl)propanoyl]oxazolidin-2-one

3-(2-phenylsulfonylacetyl)oxazolidin-2-one

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