Technology Process of ethyl 6-methyl-2-({N-methyl-N-[(4-oxo-1,4-dihydroquinazolin-2-yl)methyl]alanyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
There total 4 articles about ethyl 6-methyl-2-({N-methyl-N-[(4-oxo-1,4-dihydroquinazolin-2-yl)methyl]alanyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene;
In
water; tert-butyl alcohol;
at 0 - 20 ℃;
for 18h;
Inert atmosphere;
DOI:10.1021/jm201331s
- Guidance literature:
-
With
benzene;
anschliessend mit H2O;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 16 h / 160 °C
2.1: trichlorophosphate / 0.5 h / 0 °C / Inert atmosphere
2.2: 3 h / 84 °C / Inert atmosphere
3.1: sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 0 - 20 °C / Inert atmosphere
With
sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; trichlorophosphate;
In
water; tert-butyl alcohol;
2.1: Vilsmeier-Haack reaction / 2.2: Vilsmeier-Haack reaction;
DOI:10.1021/jm201331s
