1-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde

Base Information

• Chemical Name: 1-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde
• CAS No.: 1361236-35-2
• Molecular Formula: C₁₃H₁₄N₂O₂
• Molecular Weight: 230.266
• Mol file: 1361236-35-2.mol

Synonyms:1-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde

Chemical Property of 1-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde

There total 2 articles about 1-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-ethyl-5-methyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one (3614-49-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde (1361236-35-2)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; at 0 ℃; for 0.5h; Inert atmosphere;

1-ethyl-5-methyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one; at 84 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm201331s

Reference yield:

edaravone (89-25-8) → 1-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde (1361236-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 16 h / 160 °C

2.1: trichlorophosphate / 0.5 h / 0 °C / Inert atmosphere

2.2: 3 h / 84 °C / Inert atmosphere

With trichlorophosphate; 2.1: Vilsmeier-Haack reaction / 2.2: Vilsmeier-Haack reaction;

DOI:10.1021/jm201331s

Reference yield: 90.0%

1-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde (1361236-35-2) → 1-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (5677-69-0)

Guidance literature:

With sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 0 - 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm201331s

upstream raw materials:

1-ethyl-5-methyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one

N,N-dimethyl-formamide

edaravone

Downstream raw materials:

1-ethyl-N-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

1-ethyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid