trans-3-Oxabicyclo[3.1.0]hexane-6-Methanol

Base Information

• Chemical Name: trans-3-Oxabicyclo[3.1.0]hexane-6-Methanol
• CAS No.: 135577-15-0
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.144
• Mol file: 135577-15-0.mol

Synonyms:trans-3-Oxabicyclo[3.1.0]hexane-6-Methanol

Chemical Property of trans-3-Oxabicyclo[3.1.0]hexane-6-Methanol

Chemical Property:

• PSA: 29.46000
• LogP: -0.12890

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Oxabicyclo[3.1.0]hexan-6-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-3-Oxabicyclo[3.1.0]hexane-6-Methanol

There total 3 articles about trans-3-Oxabicyclo[3.1.0]hexane-6-Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (1R,5S,6R)-3-oxabicyclo[3.1.0]hexane-6-carboxylate (1307304-62-6) → (1R,5S,6R)-3-oxabicyclo[3.1.0]hexane-6-ylmethanol (135577-15-0,1398833-81-2)

Guidance literature:

tert-butyl (1R,5S,6R)-3-oxabicyclo[3.1.0]hexane-6-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at -10 - 20 ℃; for 3h;

With water; rochelle salt; In tetrahydrofuran; diethyl ether; at -5 - 20 ℃; for 0.5h;

Reference yield:

(1R,5S,6R)-ethyl 3-oxabicyclo[3.1.0]hexane-6-carboxylate (81056-11-3) → (1R,5S,6R)-3-oxabicyclo[3.1.0]hexane-6-ylmethanol (135577-15-0,1398833-81-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

2,5-dihydrofuran (1708-29-8) + diazoacetic acid ethyl ester (623-73-4) → C6H10O2 (135637-92-2,1398833-81-2) + (1R,5S,6R)-3-oxabicyclo[3.1.0]hexane-6-ylmethanol (135577-15-0,1398833-81-2)

Guidance literature:

dirhodium tetraacetate; In dichloromethane; at 20 ℃;

upstream raw materials:

2,5-dihydrofuran

diazoacetic acid ethyl ester

tert-butyl (1R,5S,6R)-3-oxabicyclo[3.1.0]hexane-6-carboxylate

(1R,5S,6R)-ethyl 3-oxabicyclo[3.1.0]hexane-6-carboxylate

Downstream raw materials:

exo-meso-3-oxabicyclo[3.1.0]hexane-6-carbaldehyde

Refernces

• 1、 -. "HEPATITIS C VIRUS INHIBITORS". Page/Page column 40. . Retrieved 2014/05/24.
• 2、 -. "HEPATITIS C VIRUS INHIBITORS". Page/Page column 39-40. . Retrieved 2012/12/13.