2,5-Dihydrofuran

Base Information

• Chemical Name: 2,5-Dihydrofuran
• CAS No.: 1708-29-8
• Molecular Formula: C4H6 O
• Molecular Weight: 70.091
• Hs Code.: 2932.90
• European Community (EC) Number: 216-957-4
• NSC Number: 60532
• UNII: HD0TIE091T
• DSSTox Substance ID: DTXSID5051785
• Nikkaji Number: J41.176K
• Wikipedia: 2,5-Dihydrofuran
• Wikidata: Q2813802
• ChEMBL ID: CHEMBL117135
• Mol file: 1708-29-8.mol

Synonyms:2,5-dihydrofuran

Chemical Property of 2,5-Dihydrofuran

Chemical Property:

• Appearance/Colour: clear liquid
• Vapor Pressure: 145mmHg at 25°C
• Refractive Index: 1.432
• Boiling Point: 66 - 67 C
• Flash Point: 2 ºF
• PSA: 9.23000
• Density: 0.927
• LogP: 0.57280
• Storage Temp.: Store below +30°C.
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 70.041864811
• Heavy Atom Count: 5
• Complexity: 41.6

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dihydrofuran ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F
• Statements: 11-19-2017/11/19
• Safety Statements: 9-16-33

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Ethers, Other
• Canonical SMILES: C1C=CCO1

Technology Process of 2,5-Dihydrofuran

There total 61 articles about 2,5-Dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Allyl ether (557-40-4) → 2,5-dihydrofuran (1708-29-8) + ethene (74-85-1)

Guidance literature:

With tungsten; In octane; chlorobenzene; at 80 ℃; for 2h;

Reference yield: 96.1%

epoxybutene (930-22-3,62249-81-4) → 2,5-dihydrofuran (1708-29-8) + furan (110-00-9) + trans-Crotonaldehyde (123-73-9,4170-30-3)

Guidance literature:

tetra-n-heptylammonium iodide; tributyltin iodide; In para-xylene; at 109 - 117 ℃; for 0.75h;

Reference yield: 89.0%

meso-erythritol (909878-64-4,10030-58-7,188346-77-2,149-32-6) → 2,5-dihydrofuran (1708-29-8) + buta-1,3-diene (106-99-0,130983-70-9,29406-96-0,9003-17-2)

Guidance literature:

With methyltrioxorhenium(VII); In rac-3-octanol; at 170 ℃; for 2.5h; Inert atmosphere;

DOI:10.1002/anie.201203877

upstream raw materials:

methyl tetrahydrofuran-2-carboxylate

(+/-)-tetrahydrofuran-3-yl acetate

1,4-dichloro-2-butene

1,4-butenediol

Downstream raw materials:

2-methoxytetrahydrofuran

cis-8-oxabicyclo<4.3.0>non-3-ene

4-ethenylcyclohexene

2,3-dihydro-2H-furan

Refernces

The effect of ultrasound and of phosphine and phosphine-oxides on the Khand reaction

10.1016/0022-328X(88)87050-5

The research investigates methods to enhance the efficiency and yield of the Khand reaction, a process used to synthesize cyclopentenones from alkynehexacarbonyldicobalt complexes and alkenes. The study explores the impact of ultrasonic irradiation and the addition of phosphine oxides on the reaction. Key chemicals used include various alkynehexacarbonyldicobalt complexes, alkenes such as 2,5-dihydrofuran and norbornadiene, and tributylphosphine oxide. The research found that ultrasonic irradiation allows the reaction to proceed more rapidly at lower temperatures, though it does not significantly affect yields. In contrast, the addition of tributylphosphine oxide to the reaction mixture often significantly increases yields, with enhancements of up to 50% observed in some cases. The study concludes that while ultrasonic irradiation can accelerate the reaction, the use of tributylphosphine oxide is a more effective method for improving the overall yield of the Khand reaction.