FMOC-L-VALINE N-CARBOXY ANHYDRIDE

Base Information

Chemical Name:FMOC-L-VALINE N-CARBOXY ANHYDRIDE
CAS No.:129288-47-7
Molecular Formula:C₂₁H₁₉NO₅
Molecular Weight:365.386
Hs Code.:2934999090
Mol file:129288-47-7.mol

Synonyms:FMOC-L-VALINE N-CARBOXY ANHYDRIDE;Fmoc-Val-NCA;NALPHA-9-Fluorenylmethoxycarbonyl-L-valine N-carboxylic anhydride;FMOC-VALINE NCA;(S)-(9H-fluoren-9-yl)methyl 4-isopropyl-2,5-dioxooxazolidine-3-carboxylate

Suppliers and Price of FMOC-L-VALINE N-CARBOXY ANHYDRIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
FMOC-VAL-NCA 95.00%
5MG
$ 504.58

Total 10 raw suppliers

Chemical Property of FMOC-L-VALINE N-CARBOXY ANHYDRIDE

Chemical Property:

PSA：72.91000
LogP:3.87680

Purity/Quality:

98% ^*data from raw suppliers

FMOC-VAL-NCA 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of FMOC-L-VALINE N-CARBOXY ANHYDRIDE

There total 1 articles about FMOC-L-VALINE N-CARBOXY ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 24601-74-9
(S)-4-isopropyloxazolidine-2,5-dione

: 129288-47-7
Fmoc-Val-NCA

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at 2 - 5 ℃; for 2h; Yield given;
DOI:10.1021/ja00176a063

Reference yield:

: 129288-47-7
Fmoc-Val-NCA

: Pyrazine-2-carboxylic acid ((S)-1-{(S)-1-[(2S,4R)-4-benzyloxy-2-(1,1-dimethyl-2-oxo-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1: iPr₂NEt / CH₂Cl₂

2: Et₂NH / acetonitrile

3: iPr₂NEt / CH₂Cl₂

4: Et₂NH / acetonitrile

5: HOBt; EDC; iPr₂NEt / CH₂Cl₂

6: HCl / dioxane

7: EDC; HOBt / CH₂Cl₂

8: DMP / CH₂Cl₂

With hydrogenchloride; phthalic acid dimethyl ester; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2003.08.050

Reference yield:

: 129288-47-7
Fmoc-Val-NCA

: Pyrazine-2-carboxylic acid ((S)-1-{(S)-1-[(2S,4R)-4-benzyloxy-2-((S)-1-formyl-2-methoxy-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1: iPr₂NEt / CH₂Cl₂

2: Et₂NH / acetonitrile

3: iPr₂NEt / CH₂Cl₂

4: Et₂NH / acetonitrile

5: HOBt; EDC; iPr₂NEt / CH₂Cl₂

6: HCl / dioxane

7: EDC; HOBt / CH₂Cl₂

8: DMP / CH₂Cl₂

With hydrogenchloride; phthalic acid dimethyl ester; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2003.08.050