2,2-DiMethyl-3,4-dihydro-2H-1,4-benzoxazine, 97%

Base Information

• Chemical Name: 2,2-DiMethyl-3,4-dihydro-2H-1,4-benzoxazine, 97%
• CAS No.: 866089-28-3
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• Hs Code.: 2934999090
• Mol file: 866089-28-3.mol

Synonyms:2,2-DiMethyl-3,4-dihydro-2H-1,4-benzoxazine, 97%;2,2-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

Chemical Property of 2,2-DiMethyl-3,4-dihydro-2H-1,4-benzoxazine, 97%

Chemical Property:

• PSA: 21.26000
• LogP: 2.40750

Purity/Quality:

99% ^*data from raw suppliers

2,2-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It possess various biological activities.

Technology Process of 2,2-DiMethyl-3,4-dihydro-2H-1,4-benzoxazine, 97%

There total 4 articles about 2,2-DiMethyl-3,4-dihydro-2H-1,4-benzoxazine, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,2-dimethyl-2H-1,4-benzoxazine-3-one (10514-70-2) → 2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazine (866089-28-3)

Guidance literature:

2,2-dimethyl-2H-1,4-benzoxazine-3-one; With borane; In tetrahydrofuran; at 20 - 70 ℃; for 1.16667h;

With hydrogenchloride; In water; at 50 ℃; for 0.166667h;

Reference yield: 94.0%

→ 2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazine (866089-28-3)

Guidance literature:

Reference yield:

2-amino-phenol (95-55-6) → 2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazine (866089-28-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 4 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 50 °C

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2,2-dimethyl-2H-1,4-benzoxazine-3-one

2-amino-phenol

2-bromo-N-(2-hydroxyphenyl)-2-methylpropanamide

Refernces

• 1、 -. "PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS". Paragraph 00178; 00184. . Retrieved 2018/10/19.
• 2、 -. "GLYCOSIDE DERIVATIVE AND USES THEREOF". Page/Page column 61-62. . Retrieved 2011/05/06.